{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:07:27Z","timestamp":1791313647123,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy of tocilizumab (TCZ) for the treatment of juvenile idiopathic arthritis (JIA)\u2013associated uveitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter study of patients with JIA\u2010associated uveitis that was refractory to conventional immunosuppressive drugs and anti\u2013tumor necrosis factor (anti\u2010TNF) agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We assessed 25 patients (21 female; 47 affected eyes) with a mean\u2009\u00b1\u2009SD age of 18.5\u2009\u00b1\u20098.3 years. Uveitis was bilateral in 22 patients. Cystoid macular edema was present in 9 patients. Ocular sequelae found at initiation of TCZ included cataracts (n\u2009=\u200913), glaucoma (n\u2009=\u20097), synechiae (n\u2009=\u200910), band keratopathy (n\u2009=\u200912), maculopathy (n\u2009=\u20099), and amblyopia (n\u2009=\u20095). Before TCZ, patients had received corticosteroids, conventional immunosuppressive drugs, and biologic agents (median 2 [range 1\u20135]), including adalimumab (n\u2009=\u200924), etanercept (n\u2009=\u20098), infliximab (n\u2009=\u20097), abatacept (n\u2009=\u20096), rituximab (n\u2009=\u20092), anakinra (n\u2009=\u20091), and golimumab (n\u2009=\u20091). Patients received 8 mg\/kg TCZ intravenously every 4 weeks in most cases. TCZ yielded rapid and maintained improvement in all ocular parameters. After 6 months of therapy, 79.2% of patients showed improvement in anterior chamber cell numbers, and 88.2% showed improvement after 1 year. Central macular thickness measured by optical coherence tomography in patients with cystoid macular edema decreased from a mean\u2009\u00b1\u2009SD of 401.7\u2009\u00b1\u200986.8 \u03bcm to 259.1\u2009\u00b1\u200939.5 \u03bcm after 6 months of TCZ (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012). The best\u2010corrected visual acuity increased from 0.56\u2009\u00b1\u20090.35 to 0.64\u2009\u00b1\u20090.32 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). After a median follow\u2010up of 12 months, visual improvement persisted, and complete remission of uveitis was observed in 19 of 25 patients. Significant reduction in the prednisone dosage was also achieved. The main adverse effects were severe autoimmune thrombocytopenia in 1 patient, pneumonia and then autoimmune anemia and thrombocytopenia in 1 patient, and viral conjunctivitis and bullous impetigo in 1 patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCZ appears to be a useful therapy for severe refractory JIA\u2010associated uveitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.39940","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T08:58:11Z","timestamp":1475830691000},"page":"668-675","source":"Crossref","is-referenced-by-count":152,"title":["Anti\u2013Interleukin\u20106 Receptor Tocilizumab for Severe Juvenile Idiopathic Arthritis\u2013Associated Uveitis Refractory to Anti\u2013Tumor Necrosis Factor Therapy: A Multicenter Study of Twenty\u2010Five Patients"],"prefix":"10.1002","volume":"69","author":[{"given":"Vanesa","family":"Calvo\u2010R\u00edo","sequence":"first","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Santos\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Calvo","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Isabel","family":"Gonz\u00e1lez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"L\u00f3pez\u2010Montesinos","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mesquida","sequence":"additional","affiliation":[{"name":"Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ad\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-2333","authenticated-orcid":false,"given":"Mar\u00eda Victoria","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ma\u00edz","sequence":"additional","affiliation":[{"name":"Hospital Universitario Donostia San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Atanes","sequence":"additional","affiliation":[{"name":"Hospitalario Universitario de A Coru\u00f1a La Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Bravo","sequence":"additional","affiliation":[{"name":"Hospitalario Universitario Virgen de las Nieves Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Modesto","sequence":"additional","affiliation":[{"name":"Hospital Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"D\u00edaz\u2010Cordov\u00e9s","sequence":"additional","affiliation":[{"name":"Hospital Regional Universitario M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Palmou\u2010Fontana","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Loricera","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Gonz\u00e1lez\u2010Vela","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosal\u00eda","family":"Demetrio\u2010Pablo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Gonz\u00e1lez\u2010Gay","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Blanco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), and University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32825f5481"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8436-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20945"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(03)00084-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.03.014"},{"key":"e_1_2_6_7_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem053"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket256"},{"key":"e_1_2_6_10_1","first-page":"2446","article-title":"Early predictors of severe course of uveitis in oligoarticular juvenile idiopathic arthritis","volume":"29","author":"Zulian F","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0018-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273940903311999"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e31817d998f"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200312000-00013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.9.4.243.3959"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/560632"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-12-13"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210701700509"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.09.048"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2436-y"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2466-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.866254"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu266"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.05.010"},{"key":"e_1_2_6_26_1","first-page":"864","article-title":"Golimumab in uveitis previously treated with other anti\u2010TNF\u2010\u03b1 drugs: a retrospective study of three cases from a single centre and literature review","volume":"32","author":"Calvo\u2010R\u00edo V","year":"2014","journal-title":"Clin Exp Rheumatol"},{"issue":"84","key":"e_1_2_6_27_1","first-page":"S54","article-title":"Tocilizumab in uveitis refractory to other biologic drugs: a study of 3 cases and a literature review","volume":"32","author":"Calvo\u2010R\u00edo V","year":"2014","journal-title":"Clin Exp Rheumatol"},{"issue":"102","key":"e_1_2_6_28_1","first-page":"34","article-title":"The effect of biologic therapy different from infliximab or adalimumab in patients with refractory uveitis due to Beh\u00e7et's disease: results of a multicentre open\u2010label study","volume":"34","author":"Santos\u2010G\u00f3mez M","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.03.002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273940801899822"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)34001-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.03.022"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30329-7"},{"key":"e_1_2_6_35_1","first-page":"2031","article-title":"Prevalence and outcome of uveitis in a regional cohort of patients with juvenile rheumatoid arthritis","volume":"24","author":"Chalom EC","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.1.51"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3928\/01913913-20050501-08","article-title":"Chorioretinitis as a complication of pauciarticular juvenile rheumatoid arthritis","volume":"42","author":"Hacker NM","year":"2005","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/803989"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1977.04450100096010"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.13.1133"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(90)90026-R"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.094698"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.23"},{"key":"e_1_2_6_44_1","first-page":"569","article-title":"Combination therapy with methotrexate and cyclosporine A in juvenile idiopathic arthritis","volume":"20","author":"Ravelli A","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.04.038"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20359"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1523-6"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140410"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker107"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.07.001"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-306790"},{"key":"e_1_2_6_52_1","first-page":"860","article-title":"An open\u2010label trial to assess the efficacy and safety of tocilizumab in the management of juvenile idiopathic arthritis\u2010associated uveitis: preliminary results [abstract]","volume":"56","author":"Suhler EB","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39940","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:57:21Z","timestamp":1759931841000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/art.39940"],"URL":"https:\/\/doi.org\/10.1002\/art.39940","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]}}}