{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:02:56Z","timestamp":1792782176939,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["UL1-TR-000135"],"award-info":[{"award-number":["UL1-TR-000135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Objective<\/jats:title>\n Interstitial lung disease (ILD) is associated with substantial morbidity in rheumatoid arthritis (RA), but very little is known about its long\u2010term progression. This study was undertaken to investigate the progression of pulmonary disease using a large single\u2010center cohort of patients with RA\u2010associated ILD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Records of all patients with RA\u2010associated ILD seen at Mayo Clinic between 1998 and 2014, with at least 4 weeks follow\u2010up and at least 1 pulmonary function test, were identified and manually screened for study inclusion. Progression was defined as a diffusing capacity for carbon monoxide (DL\n co<\/jats:sc>\n ) <40% predicted (or patients whose illness was too advanced to undergo screening) or a forced vital capacity (FVC) <50% predicted. Time to progression was analyzed using the Kaplan\u2010Meier method.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 167 patients included in the study, 81 (49%) were female, with a mean\u2009\u00b1\u2009SD age of 67\u2009\u00b1\u200910 years at diagnosis of ILD. Median follow\u2010up time from diagnosis of ILD was 3.3 years (range 0.01\u201314.8). One\u2010third of the patients required supplemental oxygen, 40% developed DL\n co<\/jats:sc>\n <40% predicted, and 22% developed FVC <50% predicted within 5 years after ILD diagnosis. Usual interstitial pneumonia (UIP) versus nonspecific interstitial pneumonia (NSIP) was a risk factor for DL\n co<\/jats:sc>\n progression (hazard ratio 3.29 [95% confidence interval 1.28\u20138.41]). Lower DL\n co<\/jats:sc>\n and FVC at baseline increased the risk for progression to DL\n co<\/jats:sc>\n <40% predicted and FVC <50% predicted, and higher rates of change in the first 6 months also increased the risk of progression.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Progressive loss of pulmonary function is common in RA\u2010associated ILD and is worse in patients with UIP than in those with NSIP. Predictors of progression in patients with RA\u2010associated ILD may aid clinicians in identifying patients at highest risk for progression of ILD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.39971","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T06:16:16Z","timestamp":1478758576000},"page":"542-549","source":"Crossref","is-referenced-by-count":199,"title":["Progressive Decline of Lung Function in Rheumatoid Arthritis\u2013Associated Interstitial Lung Disease"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5428-0923","authenticated-orcid":false,"given":"Jorge A.","family":"Zamora\u2010Legoff","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Krause","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Ryu","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Matteson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"33","article-title":"Cause of death in 81 autopsied patients with rheumatoid arthritis","volume":"21","author":"Suzuki A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21986"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050160"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27405"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.2019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3282f798ed"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204202"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130187"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00357-2015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0894CI"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2393"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339710791330696"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.7.668"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00019210"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00038709"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740410005809"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.39971","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.39971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:57:18Z","timestamp":1759931838000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.39971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/art.39971"],"URL":"https:\/\/doi.org\/10.1002\/art.39971","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]}}}