{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:11:06Z","timestamp":1791846666726,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32\u2010AR\u2010053459"],"award-info":[{"award-number":["T32\u2010AR\u2010053459"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08\u2010AR\u2010067885"],"award-info":[{"award-number":["K08\u2010AR\u2010067885"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR\u2010069000"],"award-info":[{"award-number":["R01\u2010AR\u2010069000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR\u2010048697"],"award-info":[{"award-number":["R01\u2010AR\u2010048697"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR\u2010056702"],"award-info":[{"award-number":["R01\u2010AR\u2010056702"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01\u2010AI\u2010078907"],"award-info":[{"award-number":["P01\u2010AI\u2010078907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AR\u2010069655"],"award-info":[{"award-number":["P30\u2010AR\u2010069655"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recent studies have demonstrated that there is an inverse relationship between lymphatic egress and inflammatory arthritis in affected joints. As a model, tumor necrosis factor (TNF)\u2013transgenic mice develop advanced arthritis following draining lymph node (LN) collapse, and loss of lymphatic contractions downstream of inflamed joints. It is unknown if these lymphatic deficits are reversible. This study was undertaken to test the hypothesis that anti\u2010TNF therapy reduces advanced erosive inflammatory arthritis, associated with restoration of lymphatic contractions, repair of damaged lymphatic vessels, and evidence of increased monocyte egress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TNF\u2010transgenic mice with advanced arthritis and collapsed popliteal LNs were treated with anti\u2010TNF monoclonal antibody (10 mg\/kg weekly) or placebo for 6 weeks, and effects on knee synovitis, lymphatic vessel ultrastructure and function, and popliteal LN cellularity were assessed by ultrasound, histology, transmission electron microscopy (TEM), near\u2010infrared indocyanine green imaging, and flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anti\u2010TNF therapy significantly decreased synovitis (\u223c5\u2010fold;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 versus placebo), restored lymphatic contractions, and significantly increased the number of popliteal LN monocyte\/macrophages (\u223c2\u2010fold;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 versus placebo). TEM demonstrated large activated macrophages attached to damaged lymphatic endothelium in mice with early arthritis, extensively damaged lymphatic vessels in placebo\u2010treated mice with advanced arthritis, and rolling leukocytes in repaired lymphatic vessels in mice responsive to anti\u2010TNF therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support the concept that anti\u2010TNF therapy ameliorates erosive inflammatory arthritis, in part via restoration of lymphatic vessel contractions and potential enhancement of inflammatory cell egress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.40047","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T14:07:50Z","timestamp":1485266870000},"page":"1187-1193","source":"Crossref","is-referenced-by-count":53,"title":["Brief Report: Treatment of Tumor Necrosis Factor\u2013Transgenic Mice With Anti\u2013Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte\/Macrophage Egress"],"prefix":"10.1002","volume":"69","author":[{"given":"Echoe M.","family":"Bouta","sequence":"first","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kuzin","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University Camden New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"de Mesy Bentley","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald W.","family":"Wood","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homaira","family":"Rahimi","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Cheng","family":"Ji","sequence":"additional","affiliation":[{"name":"Oita University Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Ritchlin","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bottaro","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University Camden New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianping","family":"Xing","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry Rochester New 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