{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:55:28Z","timestamp":1789836928740,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["4\u2010344\u20103\u2010105"],"award-info":[{"award-number":["4\u2010344\u20103\u2010105"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Genetic factors underlying susceptibility to rheumatoid arthritis (RA) in Arab populations are largely unknown. This genome\u2010wide association study (GWAS) was undertaken to explore the generalizability of previously reported RA loci to Arab subjects and to discover new Arab\u2010specific genetic loci.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Genetics of Rheumatoid Arthritis in Some Arab States Study was designed to examine the genetics and clinical features of RA patients from Jordan, the Kingdom of Saudi Arabia, Lebanon, Qatar, and the United Arab Emirates. In total, &gt;7 million single\u2010nucleotide polymorphisms (SNPs) were tested for association with RA overall and with seropositive or seronegative RA in 511 RA cases and 352 healthy controls. In addition, replication of 15 signals was attempted in 283 RA cases and 221 healthy controls. A genetic risk score of 68 known RA SNPs was also examined in this study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three loci (<jats:italic>HLA<\/jats:italic> region, intergenic 5q13, and 17p13 at <jats:italic>SMTNL2\/GGT6<\/jats:italic>) reached genome\u2010wide significance in the analyses of association with RA and with seropositive RA, and for all 3 loci, evidence of independent replication was demonstrated. Consistent with the findings in European and East Asian populations, the association of RA with <jats:italic>HLA\u2013DRB1<\/jats:italic> amino acid position 11 conferred the strongest effect (<jats:italic>P =<\/jats:italic> 4.8 \u00d7 10<jats:sup>\u221216<\/jats:sup>), and a weighted genetic risk score of previously associated RA loci was found to be associated with RA (<jats:italic>P<\/jats:italic>\u2009=\u20093.41 \u00d7 10<jats:sup>\u22125<\/jats:sup>) and with seropositive RA (<jats:italic>P<\/jats:italic>\u2009=\u20091.48 \u00d7 10<jats:sup>\u22126<\/jats:sup>) in this population. In addition, 2 novel associations specific to Arab populations were found at the 5q13 and 17p13 loci.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This first RA GWAS in Arab populations confirms that established <jats:italic>HLA<\/jats:italic>\u2010region and known RA risk alleles contribute strongly to the risk and severity of disease in some Arab groups, suggesting that the genetic architecture of RA is similar across ethnic groups. Moreover, this study identified 2 novel RA risk loci in Arabs, offering further population\u2010specific insights into the pathophysiology of RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40051","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T14:07:08Z","timestamp":1485266828000},"page":"976-985","source":"Crossref","is-referenced-by-count":30,"title":["A Multinational Arab Genome\u2010Wide Association Study Identifies New Genetic Associations for Rheumatoid Arthritis"],"prefix":"10.1002","volume":"69","author":[{"given":"Richa","family":"Saxena","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and Broad Institute Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Plenge","sequence":"additional","affiliation":[{"name":"Broad Institute, Cambridge, Massachusetts, and Merck Research Laboratories and Brigham and Women's 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