{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:56:10Z","timestamp":1790873770160,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01\u2010AI\u2010073693"],"award-info":[{"award-number":["P01\u2010AI\u2010073693"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000878","name":"S.L.E. Lupus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Objective<\/jats:title>IgG anti\u2010DWEYS<\/jats:styled-content> antibodies cross\u2010reactive with DNA<\/jats:styled-content> and the N<\/jats:italic>\u2010methyl\u2010d<\/jats:sc>\u2010aspartate receptor subunits GluN2A and GluN2B are known to be associated with neuropsychiatric systemic lupus erythematosus (NPSLE<\/jats:styled-content>). IgG anti\u2010DWEYS<\/jats:styled-content> have not been investigated in demyelinating NPSLE<\/jats:styled-content> or in another demyelinating disorder, neuromyelitis optica spectrum disorder (NMOSD<\/jats:styled-content>), which is a disease also found mainly in young women and associated with aquaporin 4 (AQP<\/jats:styled-content>\u20104) or myelin oligodendrocyte glycoprotein (MOG<\/jats:styled-content>) antibodies. This study was undertaken to investigate the frequency of all of these brain\u2010reactive antibodies in patients with NPSLE<\/jats:styled-content>, those with demyelinating NPSLE<\/jats:styled-content>, and those with NMOSD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum samples from patients with NPSLE<\/jats:styled-content> (n = 108), patients with SLE<\/jats:styled-content> without neuropsychiatric manifestations (n = 38), patients with NMOSD<\/jats:styled-content> (n = 33), and healthy controls (n = 106) were assessed for the frequency of IgG anti\u2010brain antibodies as well as IgG antibodies to AQP<\/jats:styled-content>\u20104, MOG<\/jats:styled-content>, GluN2A\/GluN2B, and double\u2010stranded DNA<\/jats:styled-content> (dsDNA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Sera were positive for IgG anti\u2013AQP<\/jats:styled-content>\u20104 antibodies in 27 (82%) of 33 patients with NMOSD<\/jats:styled-content> and 3 (27%) of 11 patients with demyelinating NPSLE<\/jats:styled-content>, whereas all sera from patients with non\u2010demyelinating NPSLE<\/jats:styled-content>, patients with SLE<\/jats:styled-content>, and healthy controls were negative for IgG anti\u2013AQP<\/jats:styled-content>\u20104. IgG anti\u2010MOG<\/jats:styled-content> were detected at high titers in 3 (50%) of 6 patients with NMOSD<\/jats:styled-content> who were negative for IgG anti\u2013AQP<\/jats:styled-content>\u20104, and at low titers in 2 (18%) of 11 patients with demyelinating NPSLE<\/jats:styled-content> and 1 (1%) of 97 patients with non\u2010demyelinating NPSLE<\/jats:styled-content>. IgG antibodies to dsDNA<\/jats:styled-content> were present in 11 (33%) of 33 patients with NMOSD<\/jats:styled-content>. Only 4 (12%) of 33 patients with NMOSD<\/jats:styled-content> were positive for IgG anti\u2010DWEYS<\/jats:styled-content>, compared to 11 (29%) of 38 patients with SLE<\/jats:styled-content> and 59 (55%) of 108 patients with NPSLE<\/jats:styled-content>. IgG anti\u2010DWEYS<\/jats:styled-content> antibodies were present in 56 (58%) of 97 patients with non\u2010demyelinating NPSLE<\/jats:styled-content> and 3 (27%) of 11 patients with demyelinating NPSLE<\/jats:styled-content>. Serum IgG brain\u2010reactive antibodies were present at a similar frequency in patients with non\u2010demyelinating NPSLE<\/jats:styled-content> (72 [75%] of 96), those with demyelinating NPSLE<\/jats:styled-content> (9 [82%] of 11), and those with SLE<\/jats:styled-content> (32 [84%] of 38), but were less frequent in patients with NMOSD<\/jats:styled-content> (20 [61%] of 33).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients with demyelinating NPSLE<\/jats:styled-content> should be tested for IgG antibodies to AQP<\/jats:styled-content>\u20104, MOG<\/jats:styled-content>, and DWEYS<\/jats:styled-content>. IgG anti\u2013AQP<\/jats:styled-content>\u20104 can be considered diagnostic for NMOSD<\/jats:styled-content>, whereas none of these antibodies appear to be diagnostic for demyelinating NPSLE<\/jats:styled-content>. Moreover, IgG anti\u2010dsDNA<\/jats:styled-content> are present in patients with NMOSD<\/jats:styled-content> but are not cross\u2010reactive with IgG anti\u2010DWEYS<\/jats:styled-content>, indicating that the antigenic stimulus and mechanisms of tissue damage are potentially different between demyelinating NPSLE<\/jats:styled-content> and NMOSD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40356","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T15:42:35Z","timestamp":1509032555000},"page":"277-286","source":"Crossref","is-referenced-by-count":66,"title":["Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder"],"prefix":"10.1002","volume":"70","author":[{"given":"Simone","family":"Mader","sequence":"first","affiliation":[{"name":"The Feinstein Institute for Medical Research Manhasset New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Jeganathan","sequence":"additional","affiliation":[{"name":"The Feinstein Institute for Medical Research Manhasset New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Arinuma","sequence":"additional","affiliation":[{"name":"Kitasato University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Fujieda","sequence":"additional","affiliation":[{"name":"Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Dujmovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia University School of Medicine Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Drulovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia University School of Medicine Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Kitasato University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel N. 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