{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:56:04Z","timestamp":1792518964528,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001876"],"award-info":[{"award-number":["UL1\u2010TR\u2010001876"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2\u2010TR\u2010001877"],"award-info":[{"award-number":["KL2\u2010TR\u2010001877"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the frequency of chronic joint pain after infection with chikungunya virus in a Latin American cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional follow\u2010up of a prospective cohort of 500 patients from the Atl\u00e1ntico Department, Colombia who were clinically diagnosed as having chikungunya virus during the 2014\u20132015 epidemic was conducted. Baseline symptoms and follow\u2010up symptoms at 20 months were evaluated in serologically confirmed cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 500 patients enrolled, 485 had serologically confirmed chikungunya virus and reported joint pain status. Patients were predominantly adults (mean \u00b1\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      age 49 \u00b1 16 years) and female, had an education level of high school or less,\u00a0and were of Mestizo ethnicity. The most commonly affected joints were the small joints, including the wrists, ankles, and fingers. The initial virus symptoms lasted a median of 4 days (interquartile range [\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      ] 3\u20138 days). Sixteen percent of the participants reported missing school or work (median 4 days [\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      2\u20137 days]). After 20 months, one\u2010fourth of the participants had persistent joint pain. A multivariable analysis indicated that significant predictors of persistent joint pain included college graduate status, initial symptoms of headache or knee pain, missed work, normal activities affected, \u22654 days of initial symptoms, and \u22654 weeks of initial joint pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first report to describe the frequency of chikungunya virus\u2013related arthritis in the Americas after a 20\u2010month follow\u2010up. The high frequency of chronic disease highlights the need for the development of prevention and treatment methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.40384","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:04:40Z","timestamp":1513728280000},"page":"578-584","source":"Crossref","is-referenced-by-count":98,"title":["Frequency of Chronic Joint Pain Following Chikungunya Virus Infection"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-9867","authenticated-orcid":false,"given":"Aileen Y.","family":"Chang","sequence":"first","affiliation":[{"name":"The George Washington University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Encinales","sequence":"additional","affiliation":[{"name":"Allied Research Society Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Porras","sequence":"additional","affiliation":[{"name":"Universidad El Bosque Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Allied Research Society Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St. Patrick","family":"Reid","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A. 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