{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:36:25Z","timestamp":1784054185143,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:00:00Z","timestamp":1522454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Childhood Arthritis and Rheumatology Research Alliance (CARRA)"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>The pediatric rheumatic diseases are a heterogeneous group of rare diseases, posing a number of challenges for the use of traditional clinical and translational research methods. Innovative comparative effectiveness approaches are needed to efficiently study treatment strategies and disease outcomes. The Childhood Arthritis and Rheumatology Research Alliance (<jats:styled-content style=\"fixed-case\">CARRA<\/jats:styled-content>) developed the consensus treatment plan (<jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>) approach as a comparative effectiveness tool for research in pediatric rheumatology. <jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>s are treatment strategies, developed by consensus methods among <jats:styled-content style=\"fixed-case\">CARRA<\/jats:styled-content> members, intended to reduce variation in treatment approaches, standardize outcome measurements, and allow for comparison of the effectiveness of different approaches with the goal of improving disease outcomes. To date, <jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>s have been published for 8 different diseases and disease manifestations. The approach has been successfully piloted for juvenile localized scleroderma, systemic juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>), polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, dermatomyositis, and lupus nephritis. Large\u2010scale studies are underway for systemic <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and polyarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, with the <jats:styled-content style=\"fixed-case\">CARRA<\/jats:styled-content> patient registry serving as the data collection platform. These studies have been designed with stakeholder involvement, including active input from <jats:styled-content style=\"fixed-case\">CARRA<\/jats:styled-content> providers, patients, and parents, with the goal of increasing feasibility and ensuring the relevance of the outcomes. These studies include ancillary biologic specimen collection intended to support additional translational and mechanistic studies. Data from these ongoing <jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content> studies will provide more information on the ability of this approach to identify effective treatment strategies and improve outcomes in the pediatric rheumatic diseases.<\/jats:p>","DOI":"10.1002\/art.40395","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:02:42Z","timestamp":1515974562000},"page":"669-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans"],"prefix":"10.1002","volume":"70","author":[{"given":"Sarah","family":"Ringold","sequence":"first","affiliation":[{"name":"Seattle Children's Hospital Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Boston Children's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Feldman","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"von Scheven","sequence":"additional","affiliation":[{"name":"University of California at San Francisco Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Wallace","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine and Seattle Children's Hospital Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Huber","sequence":"additional","affiliation":[{"name":"IWK Health Centre Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Schanberg","sequence":"additional","affiliation":[{"name":"Duke Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-2866","authenticated-orcid":false,"given":"Suzanne C.","family":"Li","sequence":"additional","affiliation":[{"name":"Hackensack University Medical Center Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela F.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Fuhlbrigge","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esi M.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Hackensack University Medical Center Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,31]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090523"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27670"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.140"},{"key":"e_1_2_3_5_1","first-page":"577","article-title":"Clinical evaluation of a combination treatment with cefmenoxime and cefsulodin of severe infections in leukemia and related disorders","volume":"41","author":"Tsuda S","year":"1988","journal-title":"In Japanese. 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