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Fibroblast\u2010like synoviocytes (\n                    <jats:styled-content style=\"fixed-case\">FLS<\/jats:styled-content>\n                    ) are a major component of synovial pannus and actively participate in the pathologic progression of\n                    <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                    . How rheumatoid\n                    <jats:styled-content style=\"fixed-case\">FLS<\/jats:styled-content>\n                    acquire and sustain such a uniquely aggressive phenotype remains poorly understood. We describe the current state of knowledge of the molecular alterations in rheumatoid\n                    <jats:styled-content style=\"fixed-case\">FLS<\/jats:styled-content>\n                    at the genomic, epigenomic, transcriptomic, proteomic, and metabolomic levels, which offers a means to reconstruct the pathways leading to rheumatoid pannus. 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