{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:26:58Z","timestamp":1777141618187,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004089","name":"Krembil Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Enthesitis is an important pathophysiologic component of psoriatic arthritis (PsA). <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genes are implicated in the pathogenesis of PsA. Little is known about the relationship between <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genetic susceptibility markers and enthesitis in PsA patients. Our aim was to examine the association between <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genetic susceptibility markers and sonographic enthesitis in PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional analysis was conducted in patients with PsA. Sonographic enthesitis was assessed according to the Madrid Sonography Enthesitis Index scoring system. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genotyping was performed using sequence\u2010specific oligonucleotide probes. The association between 6 <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> susceptibility markers of PsA and the severity of sonographic enthesitis was assessed using multivariate regression models adjusted for age, sex, body mass index, and disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred twenty\u2010five patients were included, 57.8% of whom were men. The mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> age was 56.1 \u00b1 12.7 years, and the mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> PsA duration was 16.9 \u00b1 12.3 years. In the multivariate regression model, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2013B*27 was associated with a higher enthesitis score (\u03b2 = 4.24 [95% confidence interval {95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>} 0.02, 8.46]), and the interaction between <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2013B*27 and PsA duration was statistically significant, showing an increasing effect of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2013B*27 with longer PsA duration (\u03b2 = 4.62 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.38, 7.86]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2013B*27 is associated with more severe sonographic enthesitis in PsA, particularly in patients with longer disease duration. This finding highlights the possible role of genetic variants in predisposing to PsA subphenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40423","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T12:46:45Z","timestamp":1516711605000},"page":"756-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Association Between <scp>HLA<\/scp> Genetic Susceptibility Markers and Sonographic Enthesitis in Psoriatic Arthritis"],"prefix":"10.1002","volume":"70","author":[{"given":"Ari","family":"Polachek","sequence":"first","affiliation":[{"name":"Toronto Western Hospital  Toronto Ontario Canada"},{"name":"Tel Aviv Sourasky Medical Center and Sackler Faculty Medical Center Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Cook","sequence":"additional","affiliation":[{"name":"University of Waterloo  Waterloo Ontario 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