{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:12:47Z","timestamp":1791364367031,"version":"4.3.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes are associated with the incidence and progression of radiographic osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>) of the knee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 8,023 knees (with 8 years of follow\u2010up) from the Osteoarthritis Initiative. Cox regression was performed on Heberden's node presence, total number, location, and symmetry (using 2 symmetry index models) obtained at baseline physical examination as well as self\u2010report of Heberden's node presence for evaluation of association with radiographic knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> incidence (development of a Kellgren\/Lawrence grade of \u22652) and progression (worsening in the medial joint space narrowing score of \u22651). Covariate adjustments relevant to <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> outcomes were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of Heberden's nodes (in 64% of the subjects) at baseline physical examinations, but not subjective self\u2010report of Heberden's nodes, was associated with radiographic knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> incidence (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 1.19 and 95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.001\u20131.402 [approached statistical significance]). Each additional Heberden's node found on physical examination was associated with knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> incidence (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.03 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.000\u20131.054] [approached statistical significance]) and progression (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.04 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.016\u20131.063]). Knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> incidence and progression were associated with Heberden's nodes located on the third digit (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.26 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.068\u20131.487] and 1.18 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.019\u20131.361], respectively) and first digit (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.186 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.992\u20131.418] [approached statistical significance] and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.26 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.084\u20131.453], respectively). Heberden's node symmetry was associated with knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> incidence (model 1 <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.09 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.997\u20131.185] [approached statistical significance]) and progression (model 2 <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.13 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.035\u20131.234]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The number of Heberden's nodes, their locations, and symmetry were associated with knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> incidence and progression over 8 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40463","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T01:09:30Z","timestamp":1519348170000},"page":"1234-1239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Brief Report: Association of Quantitative and Topographic Assessment of Heberden's Nodes With Knee Osteoarthritis: Data From the Osteoarthritis Initiative"],"prefix":"10.1002","volume":"70","author":[{"given":"Neil M.","family":"Kumar","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Hafezi\u2010Nejad","sequence":"additional","affiliation":[{"name":"University System of Maryland School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Haj\u2010Mirzaian","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida K.","family":"Haugen","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-7350","authenticated-orcid":false,"given":"Frank W.","family":"Roemer","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadpour","family":"Demehri","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4349-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.8.932"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202461"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-010-1073-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<995::AID-ANR6>3.0.CO;2-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21586"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg110"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.02.792"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.04.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.12.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198902000-00020"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2009.10.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a819a1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20356"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27574"}],"container-title":["Arthritis &amp; 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