{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:17:53Z","timestamp":1792563473938,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003180","name":"Academisch Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"\n Objective<\/jats:title>\n \n To compare magnetic resonance images (\n MRI<\/jats:styled-content>\n s) of the sacroiliac (\n SI<\/jats:styled-content>\n ) joints of healthy subjects and individuals with known mechanical strain acting upon the\n SI<\/jats:styled-content>\n joints to those of patients with axial spondyloarthritis (SpA) and patients with chronic back pain.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Three readers who had received standardized training and were blinded with regard to study group randomly scored\n MRI<\/jats:styled-content>\n s of the\n SI<\/jats:styled-content>\n joints of 172 subjects, including 47 healthy individuals without current or past back pain, 47 axial SpA patients from the Spondyloarthritis Caught Early (\n SPACE<\/jats:styled-content>\n ) cohort (with a previous\n MRI<\/jats:styled-content>\n confirmed positive for sacroiliitis), 47 controls with chronic back pain (irrespective of\n MRI<\/jats:styled-content>\n results) from the\n SPACE<\/jats:styled-content>\n cohort, 7 women with postpartum back pain, and 24 frequent runners.\n MRI<\/jats:styled-content>\n s were scored according to the Assessment of SpondyloArthritis international Society (\n ASAS<\/jats:styled-content>\n ) definition and Spondyloarthritis Research Consortium of Canada (\n SPARCC<\/jats:styled-content>\n ) index.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 47 healthy volunteers, 11 (23.4%) had an\n MRI<\/jats:styled-content>\n positive for sacroiliitis, compared to 43 (91.5%) of 47 axial SpA patients and 3 (6.4%) of 47 patients with chronic back pain. Three (12.5%) of the 24 runners and 4 (57.1%) of the 7 women with postpartum back pain had a positive\n MRI<\/jats:styled-content>\n . Using a\n SPARCC<\/jats:styled-content>\n cutoff of \u22652 for positivity, 12 (25.5%) of 47 healthy volunteers, 46 (97.9%) of 47 positive axial SpA patients, 5 (10.6%) of 47 controls with chronic back pain, 4 (16.7%) of 24 runners, and 4 (57.1%) of 7 women with postpartum back pain had positive\n MRI<\/jats:styled-content>\n s. Deep bone marrow edema (\n BME<\/jats:styled-content>\n ) lesions were not found in healthy volunteers, patients with chronic back pain, or runners, but were found in 42 (89.4%) of 47 positive axial SpA patients and in 1 (14.3%) of 7 women with postpartum back pain.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A substantial proportion of healthy individuals without current or past back pain has an\n MRI<\/jats:styled-content>\n positive for sacroiliitis according to the\n ASAS<\/jats:styled-content>\n definition. Deep (extensive)\n BME<\/jats:styled-content>\n lesions are almost exclusively found in axial SpA patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.40475","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T12:34:57Z","timestamp":1520426097000},"page":"1042-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":231,"title":["Magnetic Resonance Imaging of the Sacroiliac Joints Indicating Sacroiliitis According to the Assessment of SpondyloArthritis international Society Definition in Healthy Individuals, Runners, and Women With Postpartum Back Pain"],"prefix":"10.1002","volume":"70","author":[{"given":"Janneke","family":"de Winter","sequence":"first","affiliation":[{"name":"Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, and Zuyderland Medical Center Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manouk","family":"de Hooge","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center, Leiden, The Netherlands, and Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, and Zuyderland Medical Center Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri\u00ebtte","family":"de Jong","sequence":"additional","affiliation":[{"name":"Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, and Zuyderland Medical Center Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonneke","family":"van Hoeven","sequence":"additional","affiliation":[{"name":"Maasstad Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoek","family":"de Koning","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger Jorid","family":"Berg","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ramonda","sequence":"additional","affiliation":[{"name":"University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Baeten","sequence":"additional","affiliation":[{"name":"Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, and UCB Brussels 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