{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:38:54Z","timestamp":1789202334678,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006739","name":"Capital Foundation of Medical Development","doi-asserted-by":"publisher","award":["2016\u20102\u20104063"],"award-info":[{"award-number":["2016\u20102\u20104063"]}],"id":[{"id":"10.13039\/501100006739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571603"],"award-info":[{"award-number":["81571603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701615"],"award-info":[{"award-number":["81701615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91542121"],"award-info":[{"award-number":["91542121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Objective<\/jats:title>To investigate the associations between anti\u2013nuclear matrix protein 2 (anti\u2013NXP<\/jats:styled-content>\u20102) autoantibody levels and disease activity as well as calcinosis severity in patients with idiopathic inflammatory myopathies (IIM<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum levels of anti\u2013NXP<\/jats:styled-content>\u20102 autoantibodies were determined in 709 patients with IIM<\/jats:styled-content>s and also serially measured in the patients\u2019 sera with an in\u2010house enzyme\u2010linked immunosorbent assay using MORC<\/jats:styled-content>3 recombinant protein. Patients with anti\u2013NXP<\/jats:styled-content>\u20102 autoantibodies were divided into 2 subgroups: those with and those without calcinosis. Associations of anti\u2013NXP<\/jats:styled-content>\u20102 autoantibody levels with organ\u2010specific disease activity (using 10\u2010cm visual analog scale [VAS<\/jats:styled-content>] scores), serum creatine kinase (CK<\/jats:styled-content>) levels, and calcinosis severity were investigated in cross\u2010sectional and longitudinal analyses.<\/jats:p><\/jats:sec>Results<\/jats:title>A cross\u2010sectional analysis of 56 IIM<\/jats:styled-content> patients with anti\u2013NXP<\/jats:styled-content>\u20102 autoantibodies (38 without calcinosis and 18 with calcinosis) showed that in patients without calcinosis, the levels of anti\u2013NXP<\/jats:styled-content>\u20102 autoantibodies were positively correlated with the physician's global assessment of disease activity and muscle VAS<\/jats:styled-content> scores and serum CK<\/jats:styled-content> levels, whereas no such association was found in patients with calcinosis. Results of the longitudinal study revealed strong correlations of anti\u2013NXP<\/jats:styled-content>\u20102 antibody levels with the physician's global assessment and constitutional, cutaneous, gastrointestinal, and muscle VAS<\/jats:styled-content> scores and serum CK<\/jats:styled-content> levels in patients without calcinosis, but in patients with calcinosis, only a moderate correlation was observed between anti\u2013NXP<\/jats:styled-content>\u20102 antibody levels and the physician's global VAS<\/jats:styled-content> and constitutional VAS<\/jats:styled-content> scores. Of note, in patients without calcinosis, anti\u2013NXP<\/jats:styled-content>\u20102 autoantibodies were found to disappear during periods of clinical remission, but reappeared with disease relapse. No association between anti\u2013NXP<\/jats:styled-content>\u20102 antibody levels and the severity of calcinosis was observed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings indicate that anti\u2013NXP<\/jats:styled-content>\u20102 autoantibodies serve as a useful marker for disease activity in patients with IIM<\/jats:styled-content>s, especially in the absence of calcinosis. The differential associations observed between anti\u2013NXP<\/jats:styled-content>\u20102 autoantibody levels and disease activity suggest that there may be a phenotypic difference between patients with and those without calcinosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40491","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T07:20:14Z","timestamp":1521098414000},"page":"1288-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Differential Clinical Associations of Anti\u2013Nuclear Matrix Protein 2 Autoantibodies in Patients With Idiopathic Inflammatory Myopathies"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-4692","authenticated-orcid":false,"given":"Hanbo","family":"Yang","sequence":"first","affiliation":[{"name":"China\u2013Japan Friendship Hospital and Graduate School of Peking Union Medical College Beijing 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