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The population of elderly persons predominantly affected by <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> is growing rapidly. Since shortfalls exist in many aspects of <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content>, we conducted an anonymous survey of <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> unmet needs, prioritized by experts from the Gout, Hyperuricemia and Crystal\u2010Associated Disease Network. We provide our perspectives on the survey results, and we propose several <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> basic and clinical translational research pathways. Chondrocyte and cartilage culture systems for generating <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> crystals in\u00a0vitro and transgenic small animal <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> models are needed to better define <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> mechanism paradigms and help guide new therapies. <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> recognition, clinical research, and care would be improved by international consensus on <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> nomenclature and disease phenotype classification, better exploitation of advanced imaging, and pragmatic new point\u2010of\u2010care crystal analytic approaches for detecting <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> crystals. Clinical impacts of <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> crystals in osteoarthritis and in asymptomatic joints in elderly persons remain major unanswered questions that are rendered more difficult by current inability to therapeutically limit or dissolve the crystal deposits and assess the consequent clinical outcome. Going forward, <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> clinical research studies should define clinical settings in which articular <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> does substantial harm and should include analyses of diverse clinical phenotypes and populations. Clinical trials should identify the best therapeutic targets to limit <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> crystal deposition and associated inflammation and should include assessment of intraarticular agents. Our perspective is that such advances in basic and clinical science in <jats:styled-content style=\"fixed-case\">CPPD<\/jats:styled-content> are now within reach and can lead to better treatments for this disorder.<\/jats:p>","DOI":"10.1002\/art.40517","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T18:54:12Z","timestamp":1522695252000},"page":"1182-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Review: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition"],"prefix":"10.1002","volume":"70","author":[{"given":"Abhishek","family":"Abhishek","sequence":"first","affiliation":[{"name":"University of Nottingham UK City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyon","family":"Choi","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[{"name":"University of Nottingham UK City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann K.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Terkeltaub","sequence":"additional","affiliation":[{"name":"Veterans Affairs University of California at San Diego San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1511117"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.182"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000246"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-31696-5.00096-6"},{"key":"e_1_2_7_6_1","first-page":"819","article-title":"Prevalence of musculoskeletal conditions in an Italian population sample: results of a regional community\u2010based study. 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