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We undertook this study to compare short\u2010 and long\u2010term outcomes following achievement of <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> on the 10\u2010joint clinical Juvenile Arthritis Disease Activity Score (<jats:styled-content style=\"fixed-case\">cJADAS<\/jats:styled-content>10) and following achievement of <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> on Wallace et al's preliminary criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children recruited to the Childhood Arthritis Prospective Study, a <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> multicenter inception cohort, were selected if they were recruited prior to January 2011 and diagnosed as having oligoarthritis or rheumatoid factor\u2013negative or \u2013positive polyarthritis. One year following diagnosis, children were assessed for <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> on the <jats:styled-content style=\"fixed-case\">cJADAS<\/jats:styled-content>10 and for <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> on both Wallace et al's preliminary criteria and the <jats:styled-content style=\"fixed-case\">cJADAS<\/jats:styled-content>10. Associations were tested between those disease states and functional ability, absence of joints with limited range of motion, psychosocial health, and pain at 1 year and annually to 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 832 children, 70% were female and the majority had oligoarthritis (68%). At 1 year, 21% had achieved <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> according to both definitions, 7% according to Wallace et al's preliminary criteria alone, and 16% according to the <jats:styled-content style=\"fixed-case\">cJADAS<\/jats:styled-content>10 alone; 56% had not achieved <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content>. Only 10% of children in the entire cohort achieved <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> without also achieving <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content>. Achieving either early <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> state was associated with a greater absence of joints with limited range of motion. However, only <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> according to the <jats:styled-content style=\"fixed-case\">cJADAS<\/jats:styled-content>10 was associated with improved functional ability and psychosocial health. Achieving <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> was superior to achieving <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> in terms of short\u2010 and long\u2010term pain and the absence of joints with limited range of motion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> on the <jats:styled-content style=\"fixed-case\">cJADAS<\/jats:styled-content>10 may be preferable as a treatment target to <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> on Wallace et al's preliminary criteria in terms of both feasibility of application and long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40519","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T09:58:23Z","timestamp":1523527103000},"page":"1519-1529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Long\u2010Term Outcomes Following Achievement of Clinically Inactive Disease in Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"70","author":[{"given":"Stephanie J. W.","family":"Shoop\u2010Worrall","sequence":"first","affiliation":[{"name":"The University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M. M.","family":"Verstappen","sequence":"additional","affiliation":[{"name":"The University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet E.","family":"McDonagh","sequence":"additional","affiliation":[{"name":"The University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Baildam","sequence":"additional","affiliation":[{"name":"Alder Hey Children's NHS Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Chieng","sequence":"additional","affiliation":[{"name":"Royal Manchester Children's Hospital Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Davidson","sequence":"additional","affiliation":[{"name":"The Royal Hospital for Children, Glasgow, UK Edinburgh UK"},{"name":"The Royal Hospital for Sick Children Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Foster","sequence":"additional","affiliation":[{"name":"Great North Children's Hospital, Newcastle Hospitals NHS Foundation Trust Newcastle\u2010upon\u2010Tyne UK"},{"name":"Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiannis","family":"Ioannou","sequence":"additional","affiliation":[{"name":"University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"McErlane","sequence":"additional","affiliation":[{"name":"Great North Children's Hospital Newcastle Hospitals NHS Foundation Trust Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy R.","family":"Wedderburn","sequence":"additional","affiliation":[{"name":"University College London, Great Ormond Street Hospital NHS Foundation Trust London UK"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Thomson","sequence":"additional","affiliation":[{"name":"The University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimme L.","family":"Hyrich","sequence":"additional","affiliation":[{"name":"The University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"National Institute for Health and Care Excellence.Guidance on the use of etanercept for the treatment of juvenile idiopathic arthritis.2002. 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