{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:34:07Z","timestamp":1792056847442,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T00:00:00Z","timestamp":1532822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine risk factors for primary Sj\u00f6gren's syndrome (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>)\u2013associated lymphoma in a multicenter cohort of patients, with analysis of the predictive power of previously reported risk factors, including the presence of ectopic germinal center (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>)\u2013like structures in minor salivary gland (<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content>) biopsy tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred fifteen patients with primary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> were included, and <jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> biopsy tissue from these patients was retrospectively examined, focusing on the presence of ectopic <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010like structures. Epidemiologic, clinical, biologic, immunologic, and histologic data were collected at the time of diagnosis of primary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. Patients with non\u2010Hodgkin's lymphoma (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) were compared with those without <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> during the follow\u2010up period, using a Cox proportional hazards multiple regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> was diagnosed in 8 patients (6.96%), and ectopic <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010like structures in 19 patients (16.5%). The presence of ectopic <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010like structures was associated with a 7.8\u2010fold increased risk of lymphoma occurrence (95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.73\u201334.86 [<jats:italic>P<\/jats:italic> = 0.0075]). Other independent predictors included a positive cryoglobulin test result (hazard ratio [HR] 7.10, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.74\u201328.92 [<jats:italic>P<\/jats:italic> = 0.006]), male sex (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 28.73, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.46\u2013144.87 [<jats:italic>P<\/jats:italic> = 0.0004]), sensorimotor neuropathy (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 35.48, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 5.79\u2013217.39 [<jats:italic>P<\/jats:italic> = 0.0001]), and splenomegaly (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 19.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.4\u201390 [<jats:italic>P<\/jats:italic> = 0.0001]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of ectopic <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010like structures in <jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> biopsy tissue is associated with the risk of lymphoma in patients with primary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. These data reinforce the major role of <jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> biopsy tissue in primary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>, for the identification a priori of a subgroup of patients with the highest risk of lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40528","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T17:13:30Z","timestamp":1524071610000},"page":"1481-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Ectopic Germinal Center\u2013Like Structures in Minor Salivary Gland Biopsy Tissue Predict Lymphoma Occurrence in Patients With Primary Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"70","author":[{"given":"Damien","family":"S\u00e8ne","sequence":"first","affiliation":[{"name":"Lariboisi\u00e8re Fernand Widal Hospital AP\u2010HP and Universit\u00e9 Paris Diderot Sorbonne Paris 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