{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:40:21Z","timestamp":1793814021300,"version":"4.6.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17ek0109104 and JP17ek0109121"],"award-info":[{"award-number":["JP17ek0109104 and JP17ek0109121"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["nannti\u2010ippann\u2010004"],"award-info":[{"award-number":["nannti\u2010ippann\u2010004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate clinical links between levels of myeloperoxidase (<jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>)\u2013antineutrophil cytoplasmic antibody (<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>) and relapse in patients with <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>\u2010associated vasculitis (<jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>) using a data set from 2 nationwide prospective cohort studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the cohort studies, <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>\u2013positive patients who achieved remission during the 6 months after remission induction therapy were enrolled. We measured <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> levels at months 0, 3, 6, 12, 18, 24, and at the time of relapse. The primary outcome measure was relapse. A nested case\u2013control analysis and multivariable analysis were performed to investigate the relationship between <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> reappearance and relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 271 patients, 183 were classified as having microscopic polyangiitis, 34 as having granulomatosis with polyangiitis, 15 as having eosinophilic granulomatosis with polyangiitis, and 39 were unclassifiable. The median age was 73 years, and 165 (61%) were female. In 195 patients (72%), <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> levels decreased to normal levels within 6 months after commencement of treatment, and <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> reappeared in 73 of 181 patients (40%) with complete follow\u2010up data. Reappearance of <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> was more frequent in patients with relapse than in 75 age\u2010 and sex\u2010matched control patients without relapse (odds ratio 26.2 [95% confidence interval 8.2\u2013101], <jats:italic>P<\/jats:italic> &lt; 0.0001) after adjustment for confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reappearance of <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> could be a clinically useful biomarker for predicting relapse in patients with <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>\u2013positive <jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content> in remission. This suggests that routine <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> monitoring should be implemented in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40538","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T02:01:32Z","timestamp":1527040892000},"page":"1626-1633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Association Between Reappearance of Myeloperoxidase\u2013Antineutrophil Cytoplasmic Antibody and Relapse in Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitis"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-086X","authenticated-orcid":false,"given":"Haruki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010Ei","family":"Sada","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Harigai","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Amano","sequence":"additional","affiliation":[{"name":"Saitama Medical Center Saitama Medical University Kawagoe 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