{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:15:38Z","timestamp":1790194538099,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01ER0812"],"award-info":[{"award-number":["FKZ 01ER0812"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ER0813"],"award-info":[{"award-number":["01ER0813"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ER0828"],"award-info":[{"award-number":["01ER0828"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"\n Objective<\/jats:title>\n \n To analyze the prognostic value of demographic, clinical, and therapeutic factors and laboratory biomarkers and to assess their role in predicting uveitis occurrence in patients with juvenile idiopathic arthritis (\n JIA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with\n JIA<\/jats:styled-content>\n were enrolled within the first year after\n JIA<\/jats:styled-content>\n diagnosis. Demographic and clinical parameters were documented. Serum samples were collected at study enrollment, at 3\u2010month follow\u2010up visits within the first year, and then every 6 months. A multivariable Cox regression analysis was performed to evaluate the impact of demographic, clinical, laboratory, and therapeutic parameters on uveitis onset.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We included 954\n JIA<\/jats:styled-content>\n patients (67.2% female, 54.2% antinuclear antibody [\n ANA<\/jats:styled-content>\n ] positive, mean \u00b1\n SD<\/jats:styled-content>\n age at onset 7.1 \u00b1 4.6 years). Uveitis occurred in 133 patients (observation period 44.5 months). Young age at\n JIA<\/jats:styled-content>\n onset and\n ANA<\/jats:styled-content>\n positivity were significantly associated with the onset of uveitis (both\n P<\/jats:italic>\n < 0.001). Treatment of arthritis with methotrexate alone (hazard ratio [HR] 0.18 [95% confidence interval (95% CI) 0.12\u20130.29],\n P<\/jats:italic>\n < 0.001) or combined with etanercept (HR 0.10 [95% CI 0.04\u20130.23],\n P<\/jats:italic>\n < 0.001) or adalimumab (HR 0.09 [95% CI 0.01\u20130.61],\n P<\/jats:italic>\n = 0.014) reduced the risk of uveitis onset and the occurrence of uveitis\u2010related complications. Predictors of uveitis onset included elevated erythrocyte sedimentation rate at baseline (\n HR<\/jats:styled-content>\n 2.36 [95%\n CI<\/jats:styled-content>\n 1.38\u20134.02],\n P<\/jats:italic>\n = 0.002) and continuing moderate or high disease activity during follow\u2010up as measured by the 10\u2010joint clinical Juvenile Arthritis Disease Activity Score (\n HR<\/jats:styled-content>\n 4.30 [95%\n CI<\/jats:styled-content>\n 2.51\u20137.37],\n P<\/jats:italic>\n < 0.001). Additionally, S100A12 levels \u2265250 ng\/ml at baseline were significantly associated with the risk of uveitis (\n HR<\/jats:styled-content>\n 2.10 [95%\n CI<\/jats:styled-content>\n 1.15\u20133.85],\n P<\/jats:italic>\n = 0.016).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Apart from demographic risk factors and treatment modalities,\n JIA<\/jats:styled-content>\n disease activity scores and laboratory biomarkers could be used to better define the group of\n JIA<\/jats:styled-content>\n patients at high risk of uveitis onset.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.40544","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T01:05:34Z","timestamp":1525655134000},"page":"1685-1694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Risk Factors and Biomarkers for the Occurrence of Uveitis in Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6907-1112","authenticated-orcid":false,"given":"Christoph","family":"Tappeiner","sequence":"first","affiliation":[{"name":"Inselspital, University of Bern, Bern, Switzerland German Rheumatism Research Center, Berlin, Germany, and St. Franziskus Hospital Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Klotsche","sequence":"additional","affiliation":[{"name":"German Rheumatism Research Center and Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sengler","sequence":"additional","affiliation":[{"name":"German Rheumatism Research Center Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Niewerth","sequence":"additional","affiliation":[{"name":"German Rheumatism Research Center Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Liedmann","sequence":"additional","affiliation":[{"name":"German Rheumatism Research Center Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"Walscheid","sequence":"additional","affiliation":[{"name":"St. Franziskus Hospital Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miha","family":"Lavric","sequence":"additional","affiliation":[{"name":"University of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Foell","sequence":"additional","affiliation":[{"name":"University of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Minden","sequence":"additional","affiliation":[{"name":"German Rheumatism Research Center and Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Heiligenhaus","sequence":"additional","affiliation":[{"name":"St. Franziskus Hospital Muenster 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