{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:51:23Z","timestamp":1790790683136,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the link between extraarticular manifestations (<jats:styled-content style=\"fixed-case\">EAM<\/jats:styled-content>s) and baseline characteristics in patients with axial spondyloarthritis (SpA), and to define their potentially differential prognostic value in 2 large, independent Belgian axial SpA cohorts with distinct recruitment periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Information on demographic and clinical characteristics and extraarticular manifestations (<jats:styled-content style=\"fixed-case\">EAM<\/jats:styled-content>s) was obtained from patients with axial SpA originating from the (Be)Giant (Belgian Inflammatory Arthritis and Spondylitis) cohort, which includes consecutive axial SpA patients whose data have been collected since 2010, and from the <jats:styled-content style=\"fixed-case\">ASPECT<\/jats:styled-content> (Ankylosing Spondylitis Patients Epidemiological Cross\u2010sectional Trial) cohort, a Belgian registry of cross\u2010sectional data collected between February 2004 and February 2005 from consecutive patients with ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) or probable <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 1,250 Belgian patients studied, disease duration was associated with risk of developing inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>), with an increase in risk by 20% per 10 years of disease duration (relative risk [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>] 1.2, <jats:italic>P<\/jats:italic> = 0.026), and associated with risk of developing acute anterior uveitis, with an increase in risk by 30% per 10 years of disease duration (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.3, <jats:italic>P<\/jats:italic> &lt; 0.001). In the subgroup of 171 newly diagnosed patients with prospective follow\u2010up data, higher mean C\u2010reactive protein levels over time were demonstrated in those with acute anterior uveitis or <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> compared to those without <jats:styled-content style=\"fixed-case\">EAM<\/jats:styled-content>s or those with psoriasis alone (each <jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of developing acute anterior uveitis or <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>, but not psoriasis, in patients with axial SpA seems to increase with disease duration and appears to be linked to a higher cumulative exposure to inflammation, thus providing a possible explanation for the differential structural progression observed in those with axial SpA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40551","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T03:46:01Z","timestamp":1525837561000},"page":"1588-1596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Association of Inflammatory Bowel Disease and Acute Anterior Uveitis, but Not Psoriasis, With Disease Duration in Patients With Axial Spondyloarthritis"],"prefix":"10.1002","volume":"70","author":[{"given":"Ga\u00eblle","family":"Varkas","sequence":"first","affiliation":[{"name":"Ghent University Hospital and VIB Center for Inflammation Research Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Vastesaeger","sequence":"additional","affiliation":[{"name":"Merck Sharp &amp; Dohme Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-5085","authenticated-orcid":false,"given":"Heleen","family":"Cypers","sequence":"additional","affiliation":[{"name":"Ghent University Hospital and VIB Center for Inflammation Research Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roos","family":"Colman","sequence":"additional","affiliation":[{"name":"Biostatistics Unit of the Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Renson","sequence":"additional","affiliation":[{"name":"Ghent University Hospital and VIB Center for Inflammation Research Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbet Van","family":"Praet","sequence":"additional","affiliation":[{"name":"Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Carron","sequence":"additional","affiliation":[{"name":"Ghent University Hospital and VIB Center for Inflammation Research Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Raeman","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke","family":"Devinck","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Gyselbrecht","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Corluy","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Piette","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Thevissen","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte","family":"Vanneuville","sequence":"additional","affiliation":[{"name":"(Be)Giant Consortium Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip Van den","family":"Bosch","sequence":"additional","affiliation":[{"name":"Ghent University Hospital and VIB Center for Inflammation Research Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Elewaut","sequence":"additional","affiliation":[{"name":"Ghent University Hospital and VIB Center for Inflammation Research Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205253"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.01.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24483"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33465"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24132"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.064543"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199807000-00006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.03.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203854"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.152975"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202135"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"e_1_2_7_15_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7450"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3528"},{"key":"e_1_2_7_19_1","first-page":"962","article-title":"Increased occurrence of psoriasis in patients with Crohn's disease and their relatives","volume":"85","author":"Lee FI","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2340\/0001555564557559","article-title":"Ophthalmological manifestations in patients with psoriasis","volume":"64","author":"Catsarou\u2010Catsari A","year":"1984","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv068"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001169"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301668"},{"issue":"2","key":"e_1_2_7_24_1","first-page":"ii37","article-title":"Genetic epidemiology of psoriasis and psoriatic arthritis","volume":"64","author":"Rahman P","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu388"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.5.431"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2667"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38873"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140302"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70044-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.1.73"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.3.135"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209853"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39628"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203582"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075754"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21648"},{"key":"e_1_2_7_38_1","first-page":"511","article-title":"Prevalence of ankylosing spondylitis and other spondyloarthropathies among patients with inflammatory bowel disease: a population study (the IBSEN study)","volume":"29","author":"Palm O","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i46.17463"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.991752"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.40551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.40551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:44:03Z","timestamp":1759949043000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.40551"}},"subtitle":["Results From Two Belgian Nationwide Axial Spondyloarthritis Cohorts"],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/art.40551"],"URL":"https:\/\/doi.org\/10.1002\/art.40551","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]},"assertion":[{"value":"2017-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}