{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:31:18Z","timestamp":1769826678512,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Objective<\/jats:title>Several autoimmune diseases have familial aggregation and, possibly, common genetic predispositions. In a large population\u2010based study, we evaluated whether children born to mothers with systemic lupus erythematosus (SLE<\/jats:styled-content>) have an increased risk of rheumatic and nonrheumatic autoimmune diseases versus children born to mothers without SLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Using the Offspring of SLE<\/jats:styled-content> Mothers Registry, we identified children born live to SLE<\/jats:styled-content> mothers and their matched controls, and ascertained autoimmune diseases based on \u22651 hospitalization or \u22652 physician visits with a relevant diagnostic code. We adjusted for maternal age, education, race\/ethnicity, obstetric complications, calendar birth year, and sex of child.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 509 women with SLE<\/jats:styled-content> had 719 children, while 5,824 matched controls had 8,493 children. The mean \u00b1 SD<\/jats:styled-content> follow\u2010up period was 9.1 \u00b1 5.8 years. Children born to mothers with SLE<\/jats:styled-content> had a similar frequency of rheumatic autoimmune diagnoses (0.14%; 95% confidence interval [95% CI<\/jats:styled-content>] 0.01\u20130.90) versus controls (0.19% [95% CI<\/jats:styled-content> 0.11\u20130.32]). There was a trend toward more nonrheumatic autoimmune diseases in SLE<\/jats:styled-content> offspring (1.11% [95% CI<\/jats:styled-content> 0.52\u20132.27]) versus controls (0.48% [95% CI<\/jats:styled-content> 0.35\u20130.66]). In multivariate analyses, we did not see a clear increase in rheumatic autoimmune disease (odds ratio [OR<\/jats:styled-content>] 0.71 [95% CI<\/jats:styled-content> 0.11\u20134.82]), but children born to mothers with SLE<\/jats:styled-content> had a substantially increased risk of nonrheumatic autoimmune disease versus controls (OR<\/jats:styled-content> 2.30 [95% CI<\/jats:styled-content> 1.06\u20135.03]).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Although the vast majority of offspring have no autoimmune disease, children born to women with SLE<\/jats:styled-content> may have an increased risk of nonrheumatic autoimmune diseases versus controls. Additional studies assessing offspring through to adulthood would be additionally enlightening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40570","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T03:20:19Z","timestamp":1527045619000},"page":"1796-1800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Brief Report: Risk of Childhood Rheumatic and Nonrheumatic Autoimmune Diseases in Children Born to Women With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"70","author":[{"given":"Julie","family":"Couture","sequence":"first","affiliation":[{"name":"CHU Sainte\u2010Justine Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha","family":"Bernatsky","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Scott","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Pineau","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Vinet","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20999"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1017\/S1355617797003706","article-title":"The influence of systemic lupus erythematosus on fetal development: cognitive, behavioral, and health trends","volume":"3","author":"McAllister DL","year":"1997","journal-title":"J Int Neuropsychol Soc"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2012.08.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10638"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem233"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03238.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/278495"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e35"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00246-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12214"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2929-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3528"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.121"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0653-x"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.40570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.40570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:30:40Z","timestamp":1759923040000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.40570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/art.40570"],"URL":"https:\/\/doi.org\/10.1002\/art.40570","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]},"assertion":[{"value":"2017-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}