{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:26:13Z","timestamp":1788830773038,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key R&D Program of China","award":["81430034"],"award-info":[{"award-number":["81430034"]}]},{"name":"National Key R&D Program of China","award":["91542123"],"award-info":[{"award-number":["91542123"]}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Objective<\/jats:title>Although a role for CD<\/jats:styled-content>4+ T cells in the pathogenesis of Sj\u00f6gren's syndrome (SS<\/jats:styled-content>) has been documented, the pathogenic significance of CD<\/jats:styled-content>8+ T cells is unclear. The aim of this study was to investigate the role of CD<\/jats:styled-content>8+ T cells in the development of SS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Flow cytometry and immunofluorescence analyses were utilized to detect T cell infiltration within the labial salivary glands of patients with primary SS<\/jats:styled-content>. In parallel, p40\u2212\/\u2212<\/jats:sup>CD<\/jats:styled-content>25\u2212\/\u2212<\/jats:sup> mice were used as a murine model of SS<\/jats:styled-content>. In addition, mice with genetic knockout of CD<\/jats:styled-content>4, CD<\/jats:styled-content>8a, or interferon\u2010\u03b3 (IFN<\/jats:styled-content>\u03b3) were crossed with p40\u2212\/\u2212<\/jats:sup>CD<\/jats:styled-content>25\u2212\/\u2212<\/jats:sup> mice to study the pathogenic significance of specific lineage subpopulations, including functional salivary gland tests as well as histopathologic and serologic data. A CD<\/jats:styled-content>8+ T cell\u2013specific depletion antibody was used in this murine SS<\/jats:styled-content> model to evaluate its potential as a therapeutic strategy.<\/jats:p><\/jats:sec>Results<\/jats:title>CD<\/jats:styled-content>8+ T cells with a tissue\u2010resident memory phenotype outnumbered CD<\/jats:styled-content>4+ T cells in the labial salivary glands of patients with SS<\/jats:styled-content>, and were primarily colocalized with salivary duct epithelial cells and acinar cells. Furthermore, infiltrating CD<\/jats:styled-content>8+ T cells with a CD<\/jats:styled-content>69+CD<\/jats:styled-content>103+\/\u2212 tissue\u2010resident phenotype and with a significant elevation of IFN<\/jats:styled-content>\u03b3 production were dominant in the submandibular glands of mice in this murine SS<\/jats:styled-content> model. CD<\/jats:styled-content>8a knockout abrogated the development of SS<\/jats:styled-content> in these mice. Knockout of IFN<\/jats:styled-content>\u03b3 decreased CD<\/jats:styled-content>8+ T cell infiltration and gland destruction. More importantly, depletion of CD<\/jats:styled-content>8+ T cells fully protected mice against the pathologic manifestations of SS<\/jats:styled-content>, even after the onset of disease.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These data reveal the pathogenic significance of CD<\/jats:styled-content>8+ T cells in the development and progression of SS<\/jats:styled-content> in the salivary glands. Treatment directed against CD<\/jats:styled-content>8+ T cells may be a rational therapy for the management of SS<\/jats:styled-content> in human subjects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40676","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T07:45:08Z","timestamp":1532331908000},"page":"121-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Tissue\u2010Resident Memory CD<\/scp>8+ T Cells Acting as Mediators\u00a0of Salivary Gland Damage in a Murine Model of Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"71","author":[{"given":"Cai\u2010Yue","family":"Gao","sequence":"first","affiliation":[{"name":"Institute of Immunology and School of Life Sciences University of Science and Technology of China, Hefei, China, and Institutes for Life Sciences and School of Medicine, South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Immunology and School of Life Sciences University of Science and Technology of China, Hefei, China, and Institutes for Life Sciences and School of Medicine, South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Immunology and School of Life Sciences University of Science and Technology of China, Hefei, China, and Institutes for Life Sciences and School of Medicine, South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Han","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Immunology and School of Life Sciences University of Science and Technology of China, Hefei, China, and Institutes for Life Sciences and School of Medicine, South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Hospital Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[{"name":"Institute of Health Biosciences and University of Tokushima Graduate School Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Provincial Hospital Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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