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Data on subclinical atherosclerosis, obtained through assessment of carotid intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content>) and presence\/absence of carotid plaques by carotid ultrasonography, were available for 1,355 individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A genetic variant of the <jats:italic><jats:styled-content style=\"fixed-case\">RARB<\/jats:styled-content><\/jats:italic> gene (rs116199914) was associated with <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> values at the genome\u2010wide level of significance (minor allele [G] \u03b2 coefficient 0.142, <jats:italic>P<\/jats:italic> = 1.86 \u00d7 10<jats:sup>\u22128<\/jats:sup>). Interestingly, rs116199914 overlapped with regulatory elements in tissues related to <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> pathophysiology and immune cells. In addition, biologic pathway enrichment and predictive protein\u2013protein relationship analyses, including suggestive <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content> signals of potential relevance, revealed a functional enrichment of the collagen biosynthesis network related to the presence\/absence of carotid plaques (Gene Ontology no. 0032964; false discovery rate\u2013adjusted <jats:italic>P<\/jats:italic> = 4.01 \u00d7 10<jats:sup>\u22123<\/jats:sup>). Furthermore, our data suggest potential influences of the previously described candidate <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk loci <jats:italic><jats:styled-content style=\"fixed-case\">NFKB<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">MSRA<\/jats:styled-content><\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">ZC<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>1<\/jats:italic> (<jats:italic>P<\/jats:italic> = 8.12 \u00d7 10<jats:sup>\u22124<\/jats:sup>, <jats:italic>P<\/jats:italic> = 5.94 \u00d7 10<jats:sup>\u22124<\/jats:sup>, and <jats:italic>P<\/jats:italic> = 2.46 \u00d7 10<jats:sup>\u22124<\/jats:sup>, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings strongly suggest that genetic variation within <jats:italic><jats:styled-content style=\"fixed-case\">RARB<\/jats:styled-content><\/jats:italic> contributes to the development of subclinical atherosclerosis in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40734","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T02:45:56Z","timestamp":1537843556000},"page":"351-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Identification of a 3\u2032\u2010Untranslated Genetic Variant of <i><scp>RARB<\/scp><\/i> Associated With Carotid Intima\u2010Media Thickness in Rheumatoid Arthritis: A Genome\u2010Wide Association Study"],"prefix":"10.1002","volume":"71","author":[{"given":"Raquel","family":"L\u00f3pez\u2010Mej\u00edas","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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