{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:12:47Z","timestamp":1791364367579,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T00:00:00Z","timestamp":1549670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Objective<\/jats:title>To examine the longitudinal relationship between bone mineral density (BMD<\/jats:styled-content>) and the incidence and progression of knee, hip, and hand osteoarthritis (OA<\/jats:styled-content>), and to examine the relationship between prevalent vertebral and nonvertebral fractures and the incidence and progression of OA<\/jats:styled-content> in elderly men and women in the Rotterdam Study.<\/jats:p><\/jats:sec>Methods<\/jats:title>Age\u2010 and sex\u2010specific quartiles of baseline femoral neck BMD<\/jats:styled-content> data were constructed for 4,154 subjects. Radiographs were scored for incidence and progression of knee and hip OA<\/jats:styled-content>, and for incidence of hand OA<\/jats:styled-content>. Prevalent vertebral fractures were scored using the McCloskey\/Kanis method, and prevalent nonvertebral fractures were reported by baseline interview.<\/jats:p><\/jats:sec>Results<\/jats:title>Subjects in the highest quartile of femoral neck BMD<\/jats:styled-content> had an increased risk of incident radiographic knee OA<\/jats:styled-content> (ROA<\/jats:styled-content>) (odds ratio [OR<\/jats:styled-content>] 1.58 [95% confidence interval (95% CI<\/jats:styled-content>) 1.14\u20132.18]), and an increased risk of incident hip ROA<\/jats:styled-content> (OR<\/jats:styled-content> 1.57 [95% CI<\/jats:styled-content> 1.06\u20132.32]), compared to the lowest quartile. No significant relationship was found between high femoral neck BMD<\/jats:styled-content> and progression of knee or hip ROA<\/jats:styled-content> or the incidence of hand ROA<\/jats:styled-content>. Prevalent vertebral and nonvertebral fractures were not related to an increase in the incidence or progression of knee or hip ROA<\/jats:styled-content>. However, vertebral fractures were associated with incident hand ROA<\/jats:styled-content> (OR<\/jats:styled-content> 1.74 [95% CI<\/jats:styled-content> 1.02\u20132.98]).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Results from the present study confirm earlier findings and thus provide strong evidence that high femoral neck BMD<\/jats:styled-content> is a prognostic risk factor for the development of knee and hip ROA<\/jats:styled-content>. Vertebral fractures were found to be a risk factor for incident hand ROA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40735","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T10:11:12Z","timestamp":1538129472000},"page":"361-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Are Bone Mineral Density and Fractures Related to the Incidence and Progression of Radiographic Osteoarthritis of the Knee, Hip, and Hand in Elderly Men and Women? The Rotterdam Study"],"prefix":"10.1002","volume":"71","author":[{"given":"Arjan P.","family":"Bergink","sequence":"first","affiliation":[{"name":"Erasmus Medical Center, Rotterdam, The Netherlands, and Center for Orthopedic Surgery OCON Hengelo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rivadeneira","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita M.","family":"Bierma\u2010Zeinstra","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carola","family":"Zillikens","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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