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We undertook this study to investigate the hypothesis that, using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) of the cervical spinal cord, we would observe altered frequency\u2010dependent activity in fibromyalgia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cervical spinal cord rs\u2010fMRI was conducted in fibromyalgia patients (n = 16) and healthy controls (n = 17). We analyzed the amplitude of low\u2010frequency fluctuations (ALFF), a measure of low\u2010frequency oscillatory power, for frequencies of 0.01\u20130.198 Hz and frequency sub\u2010bands to determine regional and frequency\u2010specific alterations in fibromyalgia. Functional connectivity and graph metrics were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As compared to healthy controls (n = 14), greater ventral and lesser dorsal mean ALFF of the cervical spinal cord was observed in fibromyalgia patients ( n = 15) (uncorrected <jats:italic>P<\/jats:italic> &lt; 0.05) for frequencies of 0.01\u20130.198 Hz and all sub\u2010bands. Additionally, lesser mean ALFF within the right dorsal quadrant (corrected <jats:italic>P<\/jats:italic> &lt; 0.05) for frequencies of 0.01\u20130.198 Hz and sub\u2010band frequencies of 0.073\u20130.198 Hz was observed in fibromyalgia. Regional mean ALFF was not correlated with pain; however, regional lesser mean ALFF was correlated with fatigue in patients (r = 0.763, <jats:italic>P<\/jats:italic> = 0.001). Functional connectivity and graph metrics were similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate unbalanced activity between the ventral and dorsal cervical spinal cord in fibromyalgia. Increased ventral neural processes and decreased dorsal neural processes may reflect the presence of central sensitization and contribute to fatigue and other bodily symptoms in fibromyalgia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40746","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T10:49:59Z","timestamp":1538736599000},"page":"441-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Altered Cervical Spinal Cord Resting\u2010State Activity in Fibromyalgia"],"prefix":"10.1002","volume":"71","author":[{"given":"Katherine T.","family":"Martucci","sequence":"first","affiliation":[{"name":"Stanford University, Stanford, California, and Duke University  Durham North Carolina US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Kenneth A.","family":"Weber","sequence":"additional","affiliation":[{"name":"Stanford University  Stanford California 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