{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:50:19Z","timestamp":1788367819080,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006484","name":"AbbVie Deutschland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Objective<\/jats:title>Autoantibodies against CD<\/jats:styled-content>74 (anti\u2010CD<\/jats:styled-content>74) are associated with ankylosing spondylitis (AS<\/jats:styled-content>). The present multicenter study, the International Spondyloarthritis Autoantibody (InterSpA) trial, was undertaken to compare the sensitivity and specificity of anti\u2010CD<\/jats:styled-content>74 and HLA<\/jats:styled-content>\u2013B27 in identifying patients with nonradiographic axial spondyloarthritis (axSpA).<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients ages 18\u201345 years with inflammatory back pain of \u22642 years\u2019 duration and a clinical suspicion of axSpA were recruited. HLA<\/jats:styled-content>\u2013B27 genotyping and magnetic resonance imaging of sacroiliac joints were performed in all patients. One hundred forty\u2010nine patients with chronic inflammatory back pain (IBP<\/jats:styled-content>) not caused by axSpA served as controls, and additional controls included 50 AS<\/jats:styled-content> patients and 100 blood donors whose specimens were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred patients with inflammatory back pain received a diagnosis of nonradiographic axSpA from the investigators and fulfilled the Assessment of SpondyloArthritis international Society (ASAS<\/jats:styled-content>) criteria. The mean age was 29 years, and the mean symptom duration was 12.5 months. The sensitivity of IgA anti\u2010CD<\/jats:styled-content>74 and IgG anti\u2010CD<\/jats:styled-content>74 for identifying the 100 axSpA patients was 47% and 17%, respectively. The specificity of both IgA anti\u2010CD<\/jats:styled-content>74 and IgG anti\u2010CD<\/jats:styled-content>74 was 95.3%. The sensitivity of HLA<\/jats:styled-content>\u2013B27 was 81%. The positive likelihood ratios were 10.0 (IgA anti\u2010CD<\/jats:styled-content>74), 3.6 (IgG anti\u2010CD<\/jats:styled-content>74), and 8.1 (HLA<\/jats:styled-content>\u2013B27). Assuming a 5% pretest probability of axSpA in chronic back pain patients, the posttest probability, after consideration of the respective positive test results, was 33.3% for IgA anti\u2010CD<\/jats:styled-content>74, 15.3% for IgG anti\u2010CD<\/jats:styled-content>74, and 28.8% for HLA<\/jats:styled-content>\u2013B27. A combination of IgA anti\u2010CD<\/jats:styled-content>74 and HLA<\/jats:styled-content>\u2013B27 results in a posttest probability of 80.2%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>IgA anti\u2010CD<\/jats:styled-content>74 may be a useful tool for identifying axSpA. The diagnostic value of the test in daily practice requires further confirmation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40777","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T09:05:22Z","timestamp":1542013522000},"page":"729-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Sensitivity and Specificity of Autoantibodies Against CD<\/scp>74 in Nonradiographic Axial Spondyloarthritis"],"prefix":"10.1002","volume":"71","author":[{"given":"Elke","family":"Riechers","sequence":"first","affiliation":[{"name":"Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Baerlecken","sequence":"additional","affiliation":[{"name":"Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenofon","family":"Baraliakos","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum Rheumazentrum Ruhrgebiet Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Achilles\u2010Mehr Bakhsh","sequence":"additional","affiliation":[{"name":"Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer","family":"Aries","sequence":"additional","affiliation":[{"name":"Rheumatologie Struensee\u2010Haus Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Bannert","sequence":"additional","affiliation":[{"name":"University Medical Center Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Becker","sequence":"additional","affiliation":[{"name":"Kreiskrankenhaus Blaubeuren Blaubeuren Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Brandt\u2010J\u00fcrgens","sequence":"additional","affiliation":[{"name":"Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Braun","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum Rheumazentrum Ruhrgebiet Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Ehrenstein","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg Asklepios Klinikum Bad Abbach Bad Abbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Hartwig","family":"Euler","sequence":"additional","affiliation":[{"name":"Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fleck","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg Asklepios Klinikum Bad Abbach Bad Abbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Hein","sequence":"additional","affiliation":[{"name":"Nienburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Karberg","sequence":"additional","affiliation":[{"name":"Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Matthias","sequence":"additional","affiliation":[{"name":"Aesku Diagnostics GmbH Wendelsheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Max","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Melzer","sequence":"additional","affiliation":[{"name":"Seesen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Meyer\u2010Olson","sequence":"additional","affiliation":[{"name":"Fachklinik Bad Pyrmont Bad Pyrmont Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Rech","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Rockwitz","sequence":"additional","affiliation":[{"name":"Goslar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rudwaleit","sequence":"additional","affiliation":[{"name":"Klinikum Bielefeld Rosenh\u00f6he Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Schweikhard","sequence":"additional","affiliation":[{"name":"Aesku Diagnostics GmbH Wendelsheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Sieper","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Stille","sequence":"additional","affiliation":[{"name":"Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"von Hin\u00fcber","sequence":"additional","affiliation":[{"name":"Hildesheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wagener","sequence":"additional","affiliation":[{"name":"Nienburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike\u2010Franziska","family":"Weidemann","sequence":"additional","affiliation":[{"name":"Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Zinke","sequence":"additional","affiliation":[{"name":"Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Witte","sequence":"additional","affiliation":[{"name":"Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199801)41:1<58::AID-ART8>3.0.CO;2-G"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.101501"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.014589"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-1106-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600904243"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21804"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201427"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60071-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2016.06.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202208"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202177"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21619"},{"key":"e_1_2_9_15_1","first-page":"1609","article-title":"A new scoring system for the Bath Ankylosing Spondylitis Metrology Index (BASMI)","volume":"22","author":"Jones SD","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_9_16_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.1.66"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208642"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20990"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1535-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030286"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-009-0230-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40175"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106020200"},{"issue":"10","key":"e_1_2_9_25_1","article-title":"Autoantibodies against CD74: a new diagnostic marker for spondyloarthritis (SpA) [abstract]","volume":"68","author":"Matthias T","year":"2016","journal-title":"Arthritis Rheumatol"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.40777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.40777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.40777","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.40777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:27:55Z","timestamp":1759926475000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.40777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,20]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/art.40777"],"URL":"https:\/\/doi.org\/10.1002\/art.40777","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,20]]},"assertion":[{"value":"2017-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}