{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:28:41Z","timestamp":1781270921171,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Janssen-Cilag Pharmaceuticals","award":["ISRCTN18043449"],"award-info":[{"award-number":["ISRCTN18043449"]}]},{"name":"Janssen-Cilag Pharmaceuticals","award":["2012-002640-25"],"award-info":[{"award-number":["2012-002640-25"]}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether sonographically determined subclinical enthesopathy in patients with moderate\u2010to\u2010severe psoriasis regresses with the use of ustekinumab therapy for skin disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010three patients with moderate\u2010to\u2010severe psoriasis, who were not treated with systemic therapy and did not have symptoms of psoriatic arthritis (PsA), and 23 healthy volunteers were screened by ultrasound for subclinical enthesitis. Subsequently, 23 patients with psoriasis whose ultrasound results showed inflammatory changes were treated with ustekinumab for 52 weeks. The evolution of sonographic abnormalities of the upper and lower limb entheses was assessed using an extensive gray\u2010scale and power Doppler (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) ultrasound protocol at weeks 0, 12, 24, and 52. For each parameter, a gray\u2010scale or <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> ultrasound score of &gt;0 was determined to be abnormal, and a summative score based on the Glasgow Ultrasound Enthesitis Scoring System was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all the patients with psoriasis screened using ultrasound, 49.3% had at least 1 inflammatory entheseal abnormality. Mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> inflammation scores were higher in the patients with psoriasis compared with the healthy volunteers (9.9 \u00b1 6.6 versus 1.0 \u00b1 1.4). With treatment, the mean inflammation scores decreased significantly by 42.2% from week 0 to week 24 (\u20134.2 [95% confidence interval \u20136.3, \u20132.1]; <jats:italic>P<\/jats:italic> &lt; 0.001) and by 47.5% by week 42 (\u20134.7 [95% confidence interval \u20137.1, \u20132.3]; <jats:italic>P<\/jats:italic> = 0.001). Entheseal structural abnormalities did not change significantly during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within 12 weeks of treatment, interleukin\u201012 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012)\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 inhibition for psoriasis appears to suppress subclinical enthesopathy, and the suppression is maintained through week 52. Further longitudinal studies are needed to determine whether therapy initiated for skin disease may prevent the development of PsA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40778","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T02:02:00Z","timestamp":1542938520000},"page":"626-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Regression of Peripheral Subclinical Enthesopathy in Therapy\u2010Naive Patients Treated With Ustekinumab for\u00a0Moderate\u2010to\u2010Severe Chronic Plaque Psoriasis: A Fifty\u2010Two\u2013Week, Prospective, Open\u2010Label Feasibility Study"],"prefix":"10.1002","volume":"71","author":[{"given":"Laura","family":"Savage","sequence":"first","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals NHS Trust  Leeds 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-4755","authenticated-orcid":false,"given":"Elizabeth","family":"Hensor","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Emery","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wakefield","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust Leeds, UK, and University of Bradford  Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals NHS Trust  Leeds 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