{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:26:28Z","timestamp":1790519188581,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association of ulnar artery occlusion (<jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>) assessed using Doppler ultrasound (<jats:styled-content style=\"fixed-case\">DUS<\/jats:styled-content>) with the severity markers of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred four unselected patients fulfilling the American College of Rheumatology\/European League Against Rheumatism 2013 classification criteria for <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c were included in this cross\u2010sectional multicenter study. All patients underwent bilateral hand <jats:styled-content style=\"fixed-case\">DUS<\/jats:styled-content> to evaluate the presence of <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> and clinical\/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were applied, grading the severity of <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> as \u201cno <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>,\u201d \u201conly one <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>,\u201d and \u201c<jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> on both hands,\u201d and assessing its association with clinical features of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) and 95% confidence intervals (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> was found in 76 patients (37.3%) and was bilateral in 49 patients (24%). <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> as an ordinal event was significantly associated with disease duration, history of fingertip ulcers, telangiectasia, higher modified Rodnan\u00a0skin\u00a0thickness score (<jats:styled-content style=\"fixed-case\">MRSS<\/jats:styled-content>), worse diffusing capacity for carbon monoxide (<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content><jats:sc>co<\/jats:sc>) values, higher tricuspid jet velocity, late capillaroscopic pattern, and positivity for anticentromere antibodies (<jats:styled-content style=\"fixed-case\">ACA<\/jats:styled-content>s) (univariable analysis). In the adjusted multivariable ordinal model, <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> was less frequent in women (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.35 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.15\u20130.83], <jats:italic>P<\/jats:italic> = 0.017) and in patients receiving steroids (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.24 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.09\u20130.62], <jats:italic>P<\/jats:italic> = 0.0034). In multivariable analyses, significant association with <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> was retained for history of fingertip ulcers (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.55 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.24\u20135.21], <jats:italic>P<\/jats:italic> = 0.011), higher <jats:styled-content style=\"fixed-case\">MRSS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.65 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.06\u20132.56], <jats:italic>P<\/jats:italic> =0.025), lower <jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content><jats:sc>co<\/jats:sc> values (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.85 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.78\u20130.94], <jats:italic>P<\/jats:italic> = 0.0015), and <jats:styled-content style=\"fixed-case\">ACA<\/jats:styled-content> positivity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.89 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.36\u20136.11], <jats:italic>P<\/jats:italic> = 0.0056).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> may represent a relevant severity marker of vasculopathy in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Its predictive value for the onset of severe vascular manifestations such as pulmonary arterial hypertension, and its association with mortality, remain to be determined in longitudinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40799","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T09:39:36Z","timestamp":1544866776000},"page":"983-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Ulnar Artery Occlusion and Severity Markers of Vasculopathy in Systemic Sclerosis: A Multicenter Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"71","author":[{"given":"Alain","family":"Lescoat","sequence":"first","affiliation":[{"name":"CHU Rennes, University of Rennes, INSERM, EHESP, Institut de Recherche en Sant\u00e9, Environnement et Travail (IRSET)  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile 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