{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:20:26Z","timestamp":1762431626511,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102258","N01\u2010AR\u20102\u20102259","N01\u2010AR\u20102\u20102260","N01\u2010AR\u20102\u20102261","N01\u2010AR\u20102\u20102262"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102258","N01\u2010AR\u20102\u20102259","N01\u2010AR\u20102\u20102260","N01\u2010AR\u20102\u20102261","N01\u2010AR\u20102\u20102262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore whether Heberden's nodes (<jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s) could predict magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>)\u2013based knee osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>)\u2013related osseous structural progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five hundred seventy\u2010five subjects from the Foundation for the National Institutes of Health project underwent clinical examination to evaluate <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s at baseline and knee <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> at baseline and 24 months. The <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> was read according to the semiquantitative <jats:styled-content style=\"fixed-case\">MRI OA<\/jats:styled-content> Knee Score and quantitative periarticular bone morphology measures. Adjusted linear\/logistic regression models were implemented to assess the association between the presence of <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s at baseline examination and worsening of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010defined osseous structural damage, and odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) with 95% confidence intervals (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing patients with <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s (n = 395) and patients without <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s (n = 180), more periarticular bone area expansion in the knee joint was seen in the patients with <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s over 24 months (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:sub>adj<\/jats:sub>] 1.39 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.06, 1.83], corrected <jats:italic>P<\/jats:italic> [<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub>] = 0.019), especially in the medial femur (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:sub>adj<\/jats:sub> 1.49 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05, 2.13], <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.026) and lateral femur (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:sub>adj<\/jats:sub> 2.51 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.58, 3.97], <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> &lt; 0.001), femoral notch (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:sub>adj<\/jats:sub> 1.37 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.02, 1.84], <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.04), and lateral trochlea (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:sub>adj<\/jats:sub> 1.44 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.08, 1.9], <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.012). However, a trend toward less osteophyte worsening was seen in patients with <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s in the whole knee joint (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:sub>adj<\/jats:sub> 0.63 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.40, 1.02], <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.058), particularly in the femur region (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:sub>adj<\/jats:sub> 0.54 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.31, 0.95], <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.03), compared to patients without <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>s was associated with increased <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010based periarticular bone area expansion, but less osteophyte worsening over 24 months in the knee joint, especially in the femoral region.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40811","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:36:35Z","timestamp":1547004995000},"page":"935-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Heberden's Nodes and Knee Osteoarthritis\u2013Related Osseous Structural Damage: Exploratory Study From the Osteoarthritis Initiative"],"prefix":"10.1002","volume":"71","author":[{"given":"Arya","family":"Haj\u2010Mirzaian","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore 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