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Subjects in the accelerated\n KOA<\/jats:styled-content>\n group developed\n KOA<\/jats:styled-content>\n of K\/L grade \u22653, those with typical\n KOA<\/jats:styled-content>\n showed increased K\/L radiographic scores, and those with no\n KOA<\/jats:styled-content>\n had the same K\/L grade over time. An index visit was the visit when the radiographic criteria for accelerated\n KOA<\/jats:styled-content>\n and typical\n KOA<\/jats:styled-content>\n were met (the no\n KOA<\/jats:styled-content>\n group was matched to the accelerated\n KOA<\/jats:styled-content>\n group). The observation period was up to 2 years before and after an index visit. Radiologists reviewed magnetic resonance (\n MR<\/jats:styled-content>\n ) images of the index knee and identified destabilizing meniscal tears (root tears, radial tears, complex tears), miscellaneous pathologic features (acute ligamentous or tendinous injuries, attrition, subchondral insufficiency fractures, other incidental findings), and meniscal damage in\n ><\/jats:styled-content>\n 2 of 6 regions (3 regions per meniscus: anterior horn, body, posterior horn). In addition, bone marrow lesions (\n BML<\/jats:styled-content>\n s) and cartilage damage on\n MR<\/jats:styled-content>\n images were quantified. Linear mixed regression models were performed to analyze the results.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At 1 year before the index visit, >75% of adults with accelerated\n KOA<\/jats:styled-content>\n had meniscal damage in \u22652 regions (odds ratio 3.19 [95% confidence interval 1.70\u20135.97] versus adults with typical\n KOA<\/jats:styled-content>\n ). By the index visit, meniscal damage in \u22652 regions was ubiquitous in adults with accelerated\n KOA<\/jats:styled-content>\n , including 42% of subjects having evidence of a destabilizing meniscal tear (versus 14% of subjects with typical\n KOA<\/jats:styled-content>\n ). These changes corresponded to findings of larger\n BML<\/jats:styled-content>\n s and greater cartilage loss in the accelerated\n KOA<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Accelerated\n KOA<\/jats:styled-content>\n is characterized by destabilizing meniscal tears in a knee compromised by meniscal damage in\n ><\/jats:styled-content>\n 2 regions, and also characterized by the presence of large\n BML<\/jats:styled-content>\n s and greater cartilage loss.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.40826","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T07:39:56Z","timestamp":1545982796000},"page":"1089-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Accelerated Knee Osteoarthritis Is Characterized by Destabilizing Meniscal Tears and Preradiographic Structural Disease Burden"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-4273","authenticated-orcid":false,"given":"Jeffrey B.","family":"Driban","sequence":"first","affiliation":[{"name":"Tufts Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-484X","authenticated-orcid":false,"given":"Julie E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Tufts Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori Lyn","family":"Price","sequence":"additional","affiliation":[{"name":"Tufts Medical Center and Tufts University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Ward","sequence":"additional","affiliation":[{"name":"Tufts Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"MacKay","sequence":"additional","affiliation":[{"name":"University of Cambridge School of Clinical Medicine Addenbrooke\u2019s Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles\u00a0B.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University Pawtucket Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-1839","authenticated-orcid":false,"given":"Grace H.","family":"Lo","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine and Michael E. 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