{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:04:51Z","timestamp":1775469891338,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The usefulness of positron emission tomography\u2013computed tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) with <jats:sup>18<\/jats:sup>F\u2010labeled fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010<jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>) for the diagnosis of lymphoma in patients with primary Sj\u00f6gren's syndrome (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) is unclear, since the abnormalities it reveals may be due to systemic manifestations of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. This study was undertaken to compare <jats:sup>18<\/jats:sup>F\u2010<jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> in patients with primary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> with lymphoma and those without lymphoma in order to identify patterns associated with lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted in 2 centers and included patients who met the American College of Rheumatology\/European League Against Rheumatism 2016 criteria for primary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and had undergone <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Two independent readers who were blinded with regard to lymphoma diagnosis analyzed <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans. Abnormalities were compared between patients with and those without lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 45 patients included, 15 had lymphoma. Compared to patients without lymphoma, the mean size (<jats:italic>P<\/jats:italic> = 0.048) and maximum standardized uptake value (<jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max) (<jats:italic>P<\/jats:italic> = 0.001) of the parotid glands were higher in patients with lymphoma. <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content> uptake in the lymph nodes was observed in 53.3% of the patients with lymphoma and 43.3% of the patients without lymphoma, with no difference in the number of sites, uptake pattern, or mean <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max. Focal pulmonary uptake (nodules or condensations) was observed in 5 of the patients with lymphoma (33.3%) but only 1 patient without lymphoma (3.3%) (<jats:italic>P<\/jats:italic> = 0.01). Having an <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max in the parotid gland of \u22654.7 and\/or the presence of focal pulmonary lesions was highly suggestive of lymphoma (sensitivity 80%, specificity 83.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Some systemic manifestations of primary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> (lymphadenopathy, pulmonary involvement, and salivary gland involvement) can be visualized by <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Involvement of the lymph nodes and parotid glands is commonly observed with a similar frequency in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> patients with and those without lymphoma. An <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max in the parotid glands of \u22654.7 and\/or the presence of focal lung lesions are associated with the diagnosis of lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40829","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T17:01:01Z","timestamp":1546966861000},"page":"1147-1157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Usefulness of <sup>18<\/sup>F\u2010Labeled Fluorodeoxyglucose\u2013Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"71","author":[{"given":"J\u00e9r\u00e9my","family":"Keraen","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Sud, AP\u2010HP H\u00f4pitaux Universitaires Paris\u2010Sud INSERM U1184  Le Kremlin\u2010Bic\u00eatre 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