{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:03:58Z","timestamp":1793865838383,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n Objective<\/jats:title>\n \n To determine whether novel multi\u2010energy spectral photon\u2010counting computed tomography (\n SPCCT<\/jats:styled-content>\n ) imaging can detect and differentiate between monosodium urate (\n MSU<\/jats:styled-content>\n ), calcium pyrophosphate (\n CPP<\/jats:styled-content>\n ), and hydroxyapatite (\n HA<\/jats:styled-content>\n ) crystal deposits ex vivo.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A finger with a subcutaneous gouty tophus and a calcified knee meniscus excised at the time of surgery were obtained. The finger was imaged using plain x\u2010ray, dual\u2010energy\n CT<\/jats:styled-content>\n (\n DECT<\/jats:styled-content>\n ), and multi\u2010energy\n SPCCT<\/jats:styled-content>\n . Plain x\u2010ray and multi\u2010energy\n SPCCT<\/jats:styled-content>\n images of the meniscus were acquired. For validation purposes, samples of the crystals were obtained from the tophus and meniscus, and examined by polarized light microscopy and\/or x\u2010ray diffraction. As further validation, synthetic crystal suspensions of\n MSU<\/jats:styled-content>\n ,\n CPP<\/jats:styled-content>\n , and\n HA<\/jats:styled-content>\n were scanned using multi\u2010energy\n SPCCT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Plain x\u2010ray of the gouty finger revealed bone erosions with overhanging edges.\n DECT<\/jats:styled-content>\n and multi\u2010energy\n SPCCT<\/jats:styled-content>\n both showed\n MSU<\/jats:styled-content>\n crystal deposits;\n SPCCT<\/jats:styled-content>\n was able to show finer detail. Plain x\u2010ray of the calcified meniscus showed chondrocalcinosis consistent with\n CPP<\/jats:styled-content>\n , while\n SPCCT<\/jats:styled-content>\n showed and differentiated\n CPP<\/jats:styled-content>\n and\n HA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Multi\u2010energy\n SPCCT<\/jats:styled-content>\n can not only detect, differentiate, and quantify\n MSU<\/jats:styled-content>\n crystal deposits in a gouty finger ex vivo, but also specifically detect, identify, and quantify\n CPP<\/jats:styled-content>\n within an osteoarthritic meniscus, and distinguish them from\n HA<\/jats:styled-content>\n crystal deposits. There is potential for multi\u2010energy\n SPCCT<\/jats:styled-content>\n to become useful in the diagnosis of crystal arthropathies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.40848","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T07:08:34Z","timestamp":1549264114000},"page":"1158-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Clinical Utility of Multi\u2010Energy Spectral Photon\u2010Counting Computed Tomography in Crystal Arthritis"],"prefix":"10.1002","volume":"71","author":[{"given":"Lisa K.","family":"Stamp","sequence":"first","affiliation":[{"name":"University of Otago Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel G.","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-8504","authenticated-orcid":false,"given":"Fabio","family":"Becce","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Rajeswari","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Polson","sequence":"additional","affiliation":[{"name":"University of Canterbury Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Guyen","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Viry","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Choi","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy E.","family":"Kirkbride","sequence":"additional","affiliation":[{"name":"Aara Institute of Canterbury Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir Y.","family":"Raja","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39254"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.5.261"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3461-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-018-0787-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-0221\/8\/02\/C02016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2348-3"},{"key":"e_1_2_7_8_1","first-page":"1007","article-title":"Discrimination of multiple high\u2010Z materials by multi\u2010energy spectral CT: a phantom study","volume":"3","author":"Moghiseh M","year":"2016","journal-title":"JSM Biomed Imaging Data"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/app8030467"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18394"},{"key":"e_1_2_7_11_1","first-page":"2293458","article-title":"Multi\u2010energy spectral photon\u2010counting CT in crystal\u2010related arthropathies: initial experience and diagnostic performance in vitro","volume":"10573","author":"Viry A","year":"2018","journal-title":"Proc SPIE"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.1550"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212046"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201300955"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.03.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016151109"},{"key":"e_1_2_7_17_1","unstructured":"Nature.Whales scales and moons: July's best science images.2018. 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