{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:34:52Z","timestamp":1788388492194,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2017R1A2B2008288"],"award-info":[{"award-number":["2017R1A2B2008288"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C2112"],"award-info":[{"award-number":["HI18C2112"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"\n Objective<\/jats:title>\n \n Clinical joint count assessment is important for detecting synovitis but its reliability is a subject of controversy. This study was undertaken to assess the correlation of positron emission tomography (\n PET<\/jats:styled-content>\n )\u2013derived parameters in 68 joints with disease activity and to compare the reliability of joint counts between\n PET<\/jats:styled-content>\n with computed tomography (\n CT<\/jats:styled-content>\n ) and clinical assessment in patients with rheumatoid arthritis (\n RA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We enrolled 91 patients with active\n RA<\/jats:styled-content>\n (69 in a development group and 22 in a validation group) who underwent concurrent\n 18<\/jats:sup>\n F\u2010fluorodeoxyglucose (\n 18<\/jats:sup>\n F\u2010\n FDG<\/jats:styled-content>\n )\u2013\n PET<\/jats:styled-content>\n \u2010\n CT<\/jats:styled-content>\n and clinical disease activity evaluation.\n PET<\/jats:styled-content>\n \u2010derived parameters were compared with disease activity assessed using clinical joint count parameters. A Disease Activity Score (\n DAS<\/jats:styled-content>\n ) using counts of\n PET<\/jats:styled-content>\n \u2010positive joints was developed, and then validation studies were performed in an independent group.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The number of\n PET<\/jats:styled-content>\n \u2010positive joints (of 28 and 68 joints) was significantly correlated with the swollen joint count (\n SJC<\/jats:styled-content>\n ) and tender joint count (\n TJC<\/jats:styled-content>\n ) and the\n DAS<\/jats:styled-content>\n in 28 joints using the erythrocyte sedimentation rate (\n DAS<\/jats:styled-content>\n 28\u2010\n ESR<\/jats:styled-content>\n ). Intraobserver and interobserver reliability of\n PET<\/jats:styled-content>\n for the affected joint counts were excellent. Interobserver reliability between nuclear medicine physicians and rheumatologists was good for the\n SJC<\/jats:styled-content>\n and\n TJC<\/jats:styled-content>\n in both 28 joints and 68 joints. After multivariate analyses, including\n ESR<\/jats:styled-content>\n and patient's global assessment of disease activity (Pt\n GA<\/jats:styled-content>\n ) in addition to\n PET<\/jats:styled-content>\n \u2010derived parameters, the\n PET<\/jats:styled-content>\n \/\n DAS<\/jats:styled-content>\n was derived as (0.063 \u00d7 number of\n PET<\/jats:styled-content>\n \u2010positive joints in 28 joints) + (0.011 \u00d7\n ESR<\/jats:styled-content>\n ) + (0.030 \u00d7 Pt\n GA<\/jats:styled-content>\n ). A significant correlation between the\n PET<\/jats:styled-content>\n \/\n DAS<\/jats:styled-content>\n and the\n DAS<\/jats:styled-content>\n 28\u2010\n ESR<\/jats:styled-content>\n was confirmed in the validation group (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n PET<\/jats:styled-content>\n \u2010\n CT<\/jats:styled-content>\n could serve as a sensitive and reliable method in the evaluation of disease activity in\n RA<\/jats:styled-content>\n patients, and may be applicable as a research tool, particularly in clinical trials.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.40860","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T08:08:42Z","timestamp":1550304522000},"page":"1232-1240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Development and Validation of an\n 18<\/sup>\n F\u2010Fluorodeoxyglucose\u2013Positron Emission Tomography With Computed Tomography\u2013Based Tool for the Evaluation of Joint Counts and Disease Activity in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"71","author":[{"given":"Sang Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Kyungpook National University Hospital and Kyungpook National University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hye","family":"Jeong","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong\u2010Cheol","family":"Ahn","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital and Kyungpook National University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Su","family":"Eun","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Ri","family":"Kim","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Whan","family":"Kang","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eon Jeong","family":"Nam","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital and Kyungpook National University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mo","family":"Kang","sequence":"additional","affiliation":[{"name":"Kyungpook National University Hospital and Kyungpook National University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005033221805"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000282"},{"key":"e_1_2_6_4_1","first-page":"439","article-title":"Colour Doppler ultrasonography to detect pannus in knee joint synovitis","volume":"18","author":"Schmidt WA","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.196.3.7644624"},{"key":"e_1_2_6_6_1","first-page":"956","article-title":"Assessment of disease activity in rheumatoid arthritis with 18F\u2010FDG PET","volume":"45","author":"Beckers C","year":"2004","journal-title":"J Nucl 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Effects of standardization procedures on observer dependent outcome measures","volume":"18","author":"Bellamy N","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.023929"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem286"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/annrheumdis-2018-213143","article-title":"The use of MRI\u2010detected synovitis to determine the number of involved joints for the 2010 ACR\/EULAR classification criteria for rheumatoid arthritis: is it of additional benefit?","volume":"77","author":"Boer AC","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170748"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12643"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.40860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.40860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.40860","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.40860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:03:07Z","timestamp":1759932187000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.40860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/art.40860"],"URL":"https:\/\/doi.org\/10.1002\/art.40860","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2018-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}