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This was followed by a systematic literature review and rating of the available evidence according to the <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> (Grading of Recommendations Assessment, Development and Evaluation) methodology. A group consensus process was used to compose the final recommendations and grade their strength as conditional or strong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Due to a lack of literature with good quality of evidence, recommendations were formulated on the basis of available evidence and a consensus expert opinion. Regular ophthalmic screening of children with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> is recommended because of the risk of uveitis, and the frequency of screening should be based on individual risk factors. Regular ophthalmic monitoring of children with uveitis is recommended, and intervals should be based on ocular examination findings and treatment regimen. Ophthalmic monitoring recommendations were strong primarily because of concerns of vision\u2010threatening complications of uveitis with infrequent monitoring. Topical glucocorticoids should be used as initial treatment to achieve control of inflammation. Methotrexate and the monoclonal antibody tumor necrosis factor inhibitors adalimumab and infliximab are recommended when systemic treatment is needed for the management of uveitis. The timely addition of nonbiologic and biologic drugs is recommended to maintain uveitis control in children who are at continued risk of vision loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This guideline provides direction for clinicians and patients\/parents making decisions on the screening, monitoring, and management of children with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and uveitis, using <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> methodology and informed by a consensus process with input from rheumatology and ophthalmology experts, current literature, and patient\/parent preferences and values.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40885","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:40:58Z","timestamp":1556192458000},"page":"864-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis\u2013Associated Uveitis"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-6464","authenticated-orcid":false,"given":"Sheila T.","family":"Angeles\u2010Han","sequence":"first","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ringold","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Beukelman","sequence":"additional","affiliation":[{"name":"University of Alabama  Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lovell","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Cuello","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara L.","family":"Becker","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Hospital  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Colbert","sequence":"additional","affiliation":[{"name":"National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Feldman","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary N.","family":"Holland","sequence":"additional","affiliation":[{"name":"UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly J.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine  Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Gewanter","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Richmond Virginia Commonwealth University  Richmond"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Guzman","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Horonjeff","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women\u2019s Hospital and Boston Children\u2019s Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ombrello","sequence":"additional","affiliation":[{"name":"National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray H.","family":"Passo","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina  Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Stoll","sequence":"additional","affiliation":[{"name":"University of Alabama  Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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