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Associations between anti\u2010MAA<\/jats:styled-content> antibody with RA\u2010ILD were assessed using multivariable logistic regression. Lung tissue from patients with RA\u2010ILD<\/jats:styled-content>, other ILD<\/jats:styled-content>, or emphysema, and from controls (n\u00a0= 3 per group) were stained for MAA<\/jats:styled-content>, citrulline, macrophages (CD<\/jats:styled-content>68), T cells (CD<\/jats:styled-content>3), B cells (CD<\/jats:styled-content>19\/CD<\/jats:styled-content>27), and extracellular matrix proteins (type II<\/jats:styled-content> collagen, fibronectin, vimentin). Tissue expression and colocalization with MAA<\/jats:styled-content> were quantified and compared.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 1,823 RA<\/jats:styled-content> patients, 90 had prevalent RA\u2010ILD<\/jats:styled-content>. Serum IgA and IgM anti\u2010MAA<\/jats:styled-content> antibody concentrations were higher in RA\u2010ILD<\/jats:styled-content> than in RA<\/jats:styled-content> with COPD<\/jats:styled-content> or RA<\/jats:styled-content> alone (P<\/jats:italic> = 0.005). After adjustment for covariates, the highest quartiles of IgA anti\u2010MAA<\/jats:styled-content> antibody concentration (odds ratio 2.09 [95% confidence interval 1.11\u20133.90]) and IgM (odds ratio 2.23 [95% confidence interval 1.19\u20134.15]) were significantly associated with the presence of RA\u2010ILD. MAA<\/jats:styled-content> expression in RA\u2010ILD lung tissue was greater than in tissue from all other groups (P<\/jats:italic> < 0.001), and it colocalized with citrulline (r = 0.79), CD<\/jats:styled-content>19+ B cells (r = 0.78), and extracellular matrix proteins (type II<\/jats:styled-content> collagen [r = 0.72] and vimentin [r = 0.77]) to the greatest degree in RA\u2010ILD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Serum IgA and IgM anti\u2010MAA<\/jats:styled-content> antibody is associated with ILD<\/jats:styled-content> among RA<\/jats:styled-content> patients. MAA<\/jats:styled-content> is highly expressed in RA\u2010ILD lung tissue, where it colocalizes with other RA<\/jats:styled-content> autoantigens, autoreactive B cells, and extracellular matrix proteins, highlighting its potential role in the pathogenesis of RA\u2010ILD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40900","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T10:19:22Z","timestamp":1554113962000},"page":"1483-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Malondialdehyde\u2013Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis\u2013Associated Interstitial Lung Disease"],"prefix":"10.1002","volume":"71","author":[{"given":"Bryant R.","family":"England","sequence":"first","affiliation":[{"name":"VA Nebraska\u2013Western Iowa Health Care System and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Duryee","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2013Western Iowa Health Care System and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punyasha","family":"Roul","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina D.","family":"Mahajan","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-363X","authenticated-orcid":false,"given":"Namrata","family":"Singh","sequence":"additional","affiliation":[{"name":"Iowa City VA Health Care System and University of Iowa Hospitals and Clinics Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill A.","family":"Poole","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana P.","family":"Ascherman","sequence":"additional","affiliation":[{"name":"University of Miami Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2799-3036","authenticated-orcid":false,"given":"Liron","family":"Caplan","sequence":"additional","affiliation":[{"name":"VA Eastern Colorado Health Care System and University of Colorado Denver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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