{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:50:26Z","timestamp":1774605026479,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the associations of C\u2010reactive protein (CRP) and circulating Th17\u2010associated cytokine levels with psoriatic arthritis (PsA) disease activity and therapeutic response to ustekinumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Interleukin\u201017A (IL\u201017A), IL\u201017F, IL\u201023, and CRP concentrations were measured in serum samples collected as part of the 2 PSUMMIT phase III studies of ustekinumab in PsA (n = 927). In post hoc analyses, relationships of IL\u201017A, IL\u201017F, and CRP levels at baseline, week 4, and week 24 with baseline skin and joint disease activity and response to therapy were evaluated using generalized linear models and Pearson's product\u2010moment correlation tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline serum levels of IL\u201017A and IL\u201017F were positively correlated with baseline skin disease scores (r = 0.39\u20130.62). IL\u201023 levels were correlated with skin disease scores to a lesser extent (r = 0.26\u20130.31). No significant correlations were observed between these cytokine or CRP levels and baseline joint disease activity. There was no significant association of baseline levels of IL\u201017A, IL\u201017F, IL\u201023, or CRP with therapeutic response to ustekinumab in either the skin or joints. Significant reductions from baseline in levels of IL\u201017A, IL\u201017F, and CRP were seen in patients treated with ustekinumab compared to those treated with placebo. Ustekinumab\u2010treated patients in whom 75% improvement in the Psoriasis Area and Severity Index score or 20% improvement according to the American College of Rheumatology criteria was achieved after 24 weeks of treatment had greater reductions in CRP level (geometric mean decreases of 51\u201358% versus 32\u201333%; <jats:italic>P<\/jats:italic> &lt; 0.05), but not IL\u201017A or IL\u201017F levels, than nonresponders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Baseline serum IL\u201023\/IL\u201017 levels correlated with skin, but not joint, disease activity, suggesting tissue\u2010specific variation. However, neither baseline Th17\u2010associated cytokine levels nor CRP level were predictive of therapeutic response to ustekinumab in the skin or joints, despite rapid reductions in their levels following ustekinumab therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40921","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T13:28:44Z","timestamp":1557408524000},"page":"1660-1669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Responsiveness of Serum C\u2010Reactive Protein, Interleukin\u201017A, and Interleukin\u201017F Levels to Ustekinumab in Psoriatic Arthritis: Lessons From Two Phase III, Multicenter, Double\u2010Blind, Placebo\u2010Controlled Trials"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-7311","authenticated-orcid":false,"given":"Stefan","family":"Siebert","sequence":"first","affiliation":[{"name":"University of Glasgow  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Sweet","sequence":"additional","affiliation":[{"name":"Janssen Research and Development LLC  Spring House Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bidisha","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Janssen Research and Development LLC  Spring House Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Campbell","sequence":"additional","affiliation":[{"name":"Janssen Research and Development LLC  Spring House Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-4280","authenticated-orcid":false,"given":"Iain B.","family":"McInnes","sequence":"additional","affiliation":[{"name":"University of Glasgow  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-118X","authenticated-orcid":false,"given":"Matthew J.","family":"Loza","sequence":"additional","affiliation":[{"name":"Janssen Research and Development LLC  Spring House Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60594-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204655"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204741"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38995"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.340"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314258"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60125-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810652"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.041"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.042"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201601"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141271"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40070"}],"container-title":["Arthritis &amp; 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