{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:58:08Z","timestamp":1780372688931,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Objective<\/jats:title>This study aimed to assess whether subclinical atherosclerosis, as evaluated by carotid ultrasound, could predict incident cardiovascular events (CVE<\/jats:styled-content>s) in patients with psoriatic disease (PsD) and determine whether incorporation of imaging data could improve CV<\/jats:styled-content> risk prediction by the Framingham Risk Score (FRS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In this cohort analysis, patients with PsD underwent ultrasound assessment of the carotid arteries at baseline. The extent of atherosclerosis was assessed using carotid intima\u2010media thickness (CIMT<\/jats:styled-content>) and total plaque area (TPA<\/jats:styled-content>). Incident CVE<\/jats:styled-content>s (new or recurrent) that occurred following the ultrasound assessment were identified. The association between measures of carotid atherosclerosis and the risk of developing an incident CVE<\/jats:styled-content> was evaluated using Cox proportional hazards models, with adjustment for the FRS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 559 patients with PsD were assessed, of whom 23 had incident CVE<\/jats:styled-content>s ascertained. The calculated rate of developing a first CVE<\/jats:styled-content> during the study period was 1.11 events per 100 patient\u2010years (95% confidence interval [95% CI<\/jats:styled-content>] 0.74\u20131.67). When analyzed separately in Cox proportional hazards models that were controlled for the FRS<\/jats:styled-content>, the TPA<\/jats:styled-content> (hazard ratio [HR<\/jats:styled-content>] 3.74, 95% CI<\/jats:styled-content> 1.55\u20138.85; P<\/jats:italic> = 0.003), mean CIMT<\/jats:styled-content> (HR<\/jats:styled-content> 1.21, 95% CI<\/jats:styled-content> 1.03\u20131.42; P<\/jats:italic> = 0.02), maximal CIMT<\/jats:styled-content> (HR<\/jats:styled-content> 1.11, 95% CI<\/jats:styled-content> 1.01\u20131.22; P<\/jats:italic> = 0.03), and high TPA<\/jats:styled-content> category (HR<\/jats:styled-content> 3.25, 95% CI<\/jats:styled-content> 1.18\u20138.95; P<\/jats:italic> = 0.02) were each predictive of incident CVE<\/jats:styled-content>s in patients with PsD.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The burden of carotid atherosclerosis is associated with an increased risk of developing future CVE<\/jats:styled-content>s. Combining vascular imaging data with information on traditional CV<\/jats:styled-content> risk factors could improve the accuracy of CV<\/jats:styled-content> risk stratification in patients with PsD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.40925","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T05:02:51Z","timestamp":1559710971000},"page":"1651-1659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Value of Carotid Ultrasound in Cardiovascular Risk Stratification in Patients With Psoriatic Disease"],"prefix":"10.1002","volume":"71","author":[{"given":"Curtis","family":"Sobchak","sequence":"first","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Akhtari","sequence":"additional","affiliation":[{"name":"Women's College Hospital Toronto Ontario 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