{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:17:55Z","timestamp":1793276275578,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["09\u2010111D"],"award-info":[{"award-number":["09\u2010111D"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["11\u2010203"],"award-info":[{"award-number":["11\u2010203"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["15\u2010576"],"award-info":[{"award-number":["15\u2010576"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"\n Objective<\/jats:title>\n \n To examine whether allopurinol dose escalation to achieve serum urate (\n SU<\/jats:styled-content>\n ) target can influence bone erosion or monosodium urate (\n MSU<\/jats:styled-content>\n ) crystal deposition, as measured by dual\u2010energy computed tomography (\n DECT<\/jats:styled-content>\n ) in patients with gout.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted an imaging study of a 2\u2010year randomized clinical trial that compared immediate allopurinol dose escalation to\n SU<\/jats:styled-content>\n target with conventional dosing for 1 year followed by dose escalation to target, in gout patients who were receiving allopurinol and who had an\n SU<\/jats:styled-content>\n level of \u22650.36 mmoles\/liter.\n DECT<\/jats:styled-content>\n scans of feet and radiographs of hands and feet were obtained at baseline, year 1, and year 2 visits.\n DECT<\/jats:styled-content>\n scans were scored for bone erosion and urate volume.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Paired imaging data were available for 87 patients (42 in the dose\u2010escalation group and 45 in the control group). At year 2, the progression in the CT erosion score was higher in the control group than in the dose\u2010escalation group (+7.8% versus +1.4%;\n P<\/jats:italic>\n = 0.015). Changes in plain radiography erosion or narrowing scores did not differ between groups. Reductions in\n DECT<\/jats:styled-content>\n urate volume were observed in both groups. At year 2, patients in the control group who had an\n SU<\/jats:styled-content>\n level of <0.36 mmoles\/liter and patients in the dose\u2010escalation group had reduced\n DECT<\/jats:styled-content>\n urate volume (\u221227.6 to \u221228.3%), whereas reduction in DECT urate volume was not observed in control group patients with an SU level of \u22650.36 mmoles\/liter (+1.5%) (\n P<\/jats:italic>\n = 0.023).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings provide evidence that long\u2010term urate\u2010lowering therapy using a treat\u2010to\u2010SU\u2010target strategy can influence structural damage and reduce urate crystal deposition in gout.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.40929","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T08:36:36Z","timestamp":1557736596000},"page":"1739-1746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Effects of Allopurinol Dose Escalation on Bone Erosion and Urate Volume in Gout: A Dual\u2010Energy Computed Tomography Imaging Study Within a Randomized, Controlled Trial"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"first","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Billington","sequence":"additional","affiliation":[{"name":"Auckland District Health Board Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Doyle","sequence":"additional","affiliation":[{"name":"Auckland District Health Board and University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Frampton","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opetaia","family":"Aati","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn","family":"Allan","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Drake","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Horne","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K.","family":"Stamp","sequence":"additional","affiliation":[{"name":"University of Otago Christchurch Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130408"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90501-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27356"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094201"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1105-z"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204273"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew383"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23488"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144774"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1704-y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.099713"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200976"},{"key":"e_1_2_6_14_1","first-page":"256","article-title":"Detection of erosions in the rheumatoid hand: a comparative study of multidetector computerized tomography versus magnetic resonance scanning","volume":"32","author":"Perry D","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_15_1","first-page":"577","article-title":"Treatment of chronic gout. 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