{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:39:25Z","timestamp":1791085165779,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"Objective<\/jats:title>To compare the efficacy of infliximab (IFX<\/jats:styled-content>) versus adalimumab (ADA<\/jats:styled-content>) as a first\u2010line biologic drug over 1 year of treatment in a large series of patients with refractory uveitis due to Beh\u00e7et's disease (BD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted an open\u2010label multicenter study of IFX<\/jats:styled-content> versus ADA<\/jats:styled-content> for BD<\/jats:styled-content>\u2010related uveitis refractory to conventional nonbiologic treatment. IFX<\/jats:styled-content> or ADA<\/jats:styled-content> was chosen as the first\u2010line biologic agent based on physician and patient agreement. Patients received 3\u20135 mg\/kg intravenous IFX<\/jats:styled-content> at 0, 2, and 6 weeks and every 4\u20138 weeks thereafter, or 40 mg subcutaneous ADA<\/jats:styled-content> every other week without a loading dose. Ocular parameters were compared between the 2 groups.<\/jats:p><\/jats:sec>Results<\/jats:title>The study included 177 patients (316 affected eyes), of whom 103 received IFX<\/jats:styled-content> and 74 received ADA<\/jats:styled-content>. There were no significant baseline differences between treatment groups in main demographic features, previous therapy, or ocular sign severity. After 1 year of therapy, we observed an improvement in all ocular parameters in both groups. However, patients receiving ADA<\/jats:styled-content> had significantly better outcomes in some parameters, including improvement in anterior chamber inflammation (92.31% versus 78.18% for IFX<\/jats:styled-content>; P<\/jats:italic> = 0.06), improvement in vitritis (93.33% versus 78.95% for IFX<\/jats:styled-content>; P<\/jats:italic> = 0.04), and best\u2010corrected visual acuity (mean \u00b1 SD<\/jats:styled-content> 0.81 \u00b1 0.26 versus 0.67 \u00b1 0.34 for IFX<\/jats:styled-content>; P<\/jats:italic> = 0.001). A nonsignificant difference was seen for macular thickness (mean \u00b1 SD<\/jats:styled-content> 250.62 \u00b1 36.85 for ADA<\/jats:styled-content> versus 264.89 \u00b1 59.74 for IFX<\/jats:styled-content>; P<\/jats:italic> = 0.15), and improvement in retinal vasculitis was similar between the 2 groups (95% for ADA<\/jats:styled-content> versus 97% for IFX<\/jats:styled-content>; P<\/jats:italic> = 0.28). The drug retention rate was higher in the ADA<\/jats:styled-content> group (95.24% versus 84.95% for IFX<\/jats:styled-content>; P<\/jats:italic> = 0.042).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Although both IFX<\/jats:styled-content> and ADA<\/jats:styled-content> are efficacious in refractory BD<\/jats:styled-content>\u2010related uveitis, ADA<\/jats:styled-content> appears to be associated with better outcomes than IFX<\/jats:styled-content> after 1 year of follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41026","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T16:39:23Z","timestamp":1561480763000},"page":"2081-2089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Beh\u00e7et's Disease: National Multicenter Study of 177 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