{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:44:26Z","timestamp":1792370666431,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"Objective<\/jats:title>To evaluate whether different types of sacroiliac (SI<\/jats:styled-content>) joint lesions identified by magnetic resonance imaging (MRI<\/jats:styled-content>) could differentiate axial spondyloarthritis (SpA) from conditions with buttock or pelvic pain attributable to other reasons, including postpartum women and healthy subjects.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study was designed as a prospective, cross\u2010sectional study involving 204 participants, comprising patients with axial SpA (n = 41) and control groups of subjects with or without SI<\/jats:styled-content> joint pain, including patients with lumbar disc herniation (n = 25), women with (n = 46) or without (n = 14) postpartum buttock\/pelvic pain (having given birth within the preceding 4\u201316 months), hospital cleaning staff (n = 26), long\u2010distance runners (n = 23), and healthy men (n = 29). Participants underwent clinical examination and MRI<\/jats:styled-content>, and MRI<\/jats:styled-content>s were evaluated in a blinded manner by 2 readers according to the Spondyloarthritis Research Consortium of Canada (SPARCC<\/jats:styled-content>) SI<\/jats:styled-content> joint inflammation and structural lesion scores. SPARCC<\/jats:styled-content> score cutoff levels were defined as scores above a certain threshold. Primary analyses were based on reader agreement with regard to the presence of SI<\/jats:styled-content> joint pathologic features on MRI<\/jats:styled-content> (\u201cconcordant reads\u201d). Sensitivity, specificity, and positive and negative predictive values were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>SI<\/jats:styled-content> joint ankylosis and backfill were detected by MRI<\/jats:styled-content> only in patients with axial SpA (32% and 37%, respectively), while bone marrow edema (BME<\/jats:styled-content>) and fat lesions were seen in all non\u2013axial SpA control groups (3\u201339% with BME<\/jats:styled-content> and 4\u201314% with fat lesions). SI<\/jats:styled-content> joint erosion was present only in patients with axial SpA and in women with postpartum buttock\/pelvic pain (at erosion score cutoffs of >1 and >4, 61% and 34%, respectively, in patients with axial SpA, and 9% and 2%, respectively, in women with postpartum buttock\/pelvic pain). A SPARCC BME<\/jats:styled-content> score of \u22655 was present only in patients with axial SpA (56%) and in women with postpartum buttock\/pelvic pain (24%), while fat lesions were present, albeit rarely, at high SPARCC<\/jats:styled-content> cutoff scores in nearly all groups. Of the 38 women from the non\u2010postpartum control groups who had given birth (mean time since birth 9.7 years), 2 (5%) had BME<\/jats:styled-content>, whereas none had SI<\/jats:styled-content> joint erosion or fat lesions, and none had a BME<\/jats:styled-content> score of \u22654.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>BME<\/jats:styled-content> and fat lesions were most pronounced in patients with axial SpA, but also occurred in other groups, particularly women with postpartum buttock\/pelvic pain. Erosion above a certain SPARCC<\/jats:styled-content> score threshold as well as backfill and ankylosis were highly specific for axial SpA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41037","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T03:40:15Z","timestamp":1563248415000},"page":"2034-2046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Magnetic Resonance Imaging of Lesions in the Sacroiliac Joints for Differentiation of Patients With Axial Spondyloarthritis From Control Subjects With or Without Pelvic or Buttock Pain: A Prospective, Cross\u2010Sectional Study of 204 Participants"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-7932","authenticated-orcid":false,"given":"Seng\u00fcl","family":"Seven","sequence":"first","affiliation":[{"name":"Rigshospitalet, Glostrup, Denmark, and University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3690-467X","authenticated-orcid":false,"given":"Mikkel","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Glostrup, Denmark, and University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Morsel\u2010Carlsen","sequence":"additional","affiliation":[{"name":"Rigshospitalet Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge Juul","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Rigshospitalet Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birthe","family":"Bonde","sequence":"additional","affiliation":[{"name":"Birthe Bonde Clinic of Physioterapy Copenhagen 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