{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:47:08Z","timestamp":1782283628319,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Few studies have systematically and quantitatively addressed the impact of urate\u2010lowering therapy on monosodium urate (<jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content>) deposits. This study was undertaken to analyze the effect of lifestyle measures and conventional urate\u2010lowering therapy on <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposits in patients with gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, subjects with gout according to the American College of Rheumatology\/European League Against Rheumatism classification criteria and presence of <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposits seen on dual\u2010energy computed tomography (<jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content>) scans received either lifestyle intervention or conventional urate\u2010lowering therapy for a mean period of 18 months before a follow\u2010up <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content> scan. Detected <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposits were quantified by volumetric measurement and validated by semiquantitative scoring, and baseline and follow\u2010up measurements were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline and follow\u2010up <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content> scans were available for all 83 subjects. Six subjects discontinued treatment, and 77 subjects underwent a lifestyle intervention (n = 24) or were treated with allopurinol (n = 29), febuxostat (n = 22), or benzbromarone (n = 2) over the entire observation period. The mean serum uric acid (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>) level decreased from 7.2 to 5.8 mg\/dl in the overall population. In patients who discontinued treatment, no change in <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposits or serum <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> levels was observed. The burden of <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposits significantly decreased in patients undergoing lifestyle intervention (<jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> volume <jats:italic>P<\/jats:italic> = 0.007; <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> score <jats:italic>P<\/jats:italic> = 0.001), and in patients treated with allopurinol (<jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> volume and score <jats:italic>P<\/jats:italic> &lt; 0.001) or febuxostat (<jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> volume <jats:italic>P<\/jats:italic> &lt; 0.001; <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> score <jats:italic>P<\/jats:italic> = 0.001). No significant decline in <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposits was noted in patients who discontinued treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data show that lifestyle intervention and xanthine oxidase inhibitors significantly decrease the <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposit burden. Hence, conventional gout therapy not only lowers serum <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> levels, but also reduces pathologic <jats:styled-content style=\"fixed-case\">MSU<\/jats:styled-content> deposits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41063","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T01:57:43Z","timestamp":1564365463000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effects of Conventional Uric Acid\u2013Lowering Therapy on Monosodium Urate Crystal Deposits"],"prefix":"10.1002","volume":"72","author":[{"given":"Hanna","family":"Ellmann","sequence":"first","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bayat","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Araujo","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Manger","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-7728","authenticated-orcid":false,"given":"Arnd","family":"Kleyer","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lell","sequence":"additional","affiliation":[{"name":"Klinikum Nuremberg, Radiologie Nuremberg  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Schenker","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Simon","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koray","family":"Tascilar","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert S. 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