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Net change was calculated as the difference in the probability of change from one <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> pattern to another. Wilcoxon's signed rank test was used to compare the changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven and 50 patients had baseline and follow\u2010up scans in the <jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> groups, respectively. Mean net improvements reflecting favorable changes from one <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> pattern to another in the whole lung in the <jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> groups, respectively, were as follows: from lung fibrosis to a normal lung pattern, 21% and 19%; from a ground\u2010glass pattern to a normal lung pattern, 30% and 28%; and from lung fibrosis to a ground\u2010glass pattern, 5% and 0.5%. The mean overall improvement in transitioning from a ground\u2010glass pattern or lung fibrosis to a normal lung pattern was significant for both treatments (all <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significantly favorable transitions from both ground\u2010glass and lung fibrosis <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> patterns to a normal lung pattern were observed in patients undergoing immunosuppressive treatment for <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c\u2010<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>, suggesting the usefulness of examining these transitions for insights into the underlying pathobiology of treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41085","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T09:00:11Z","timestamp":1566291611000},"page":"316-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Using Transitional Changes on High\u2010Resolution Computed Tomography to Monitor the Impact of Cyclophosphamide or Mycophenolate Mofetil on Systemic Sclerosis\u2013Related Interstitial Lung Disease"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-3489","authenticated-orcid":false,"given":"Grace Hyun J.","family":"Kim","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine at University of California, Los Angeles and University of California, Los Angeles Fielding School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald 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