{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:57:30Z","timestamp":1791896250352,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T00:00:00Z","timestamp":1588377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672129"],"award-info":[{"award-number":["81672129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971539"],"award-info":[{"award-number":["81971539"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"\n Objective<\/jats:title>\n \n Mononuclear cell infiltration and type I interferon (\n IFN<\/jats:styled-content>\n ) system activation play an important role in primary Sj\u00f6gren's syndrome (\n SS<\/jats:styled-content>\n ). We undertook this study to investigate the mechanism of poly(\n ADP<\/jats:styled-content>\n \u2010ribose) polymerase family member 9 (\n PARP<\/jats:styled-content>\n \u20109) on mononuclear cell infiltration triggered by type I\n IFN<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A proteomic study was conducted in peripheral blood mononuclear cells from patients with primary SS (n = 30) and healthy controls (n = 30) to determine differentially expressed proteins (DEPs) (\n P<\/jats:italic>\n < 0.05; fold change >1.20). Labial salivary glands (LSGs) were isolated for hematoxylin and eosin staining and immunohistochemical analysis. CD19+ B cells were purified by magnetic cell sorting for immunofluorescence staining, lentivirus\u2013PARP\u20109 transfection, and IFN\u03b1 treatment experiments. PARP\u20109 small interfering RNA (siRNA) and DTX3L siRNA were delivered into female NOD\/LtJ female mice to determine their effect.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The overexpression of PARP\u20109 and CXCL10 as well as their colocalization was confirmed in primary SS. PARP\u20109 levels in LSGs rose with increased Chisholm scores in patients with primary SS. PARP\u20109 and DTX3L were present in the infiltrating mononuclear cells from salivary glands in female NOD\/LtJ mouse models. Additionally, Ingenuity Pathway Analysis networks of DEPs demonstrated that PARP\u20109, STAT1, and IFN\u2010induced protein with tetratricopeptide repeats 1 (IFIT\u20101) participated in the IFN\u2010related pathway. Furthermore, PARP\u20109 could up\u2010regulate the expression of IFIT1 and CXCL10 in B cells. Moreover, PARP\u20109 and CXCL10 could be induced by IFN\u03b1 in B cells.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study is the first to implicate\n PARP<\/jats:styled-content>\n \u20109 as a regulator of infiltration of mononuclear cells in primary\n SS<\/jats:styled-content>\n progression and to reveal that\n PARP<\/jats:styled-content>\n \u20109 increases\n CXCL<\/jats:styled-content>\n 10 expression through up\u2010regulating\n IFIT<\/jats:styled-content>\n \u20101, which is mediated by the phosphorylation of\n STAT<\/jats:styled-content>\n 1.\n PARP<\/jats:styled-content>\n \u20109 might therefore be a novel therapeutic target for primary\n SS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.41195","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T05:22:44Z","timestamp":1577337764000},"page":"1003-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Poly(\n ADP<\/scp>\n \u2010Ribose) Polymerase Enhances Infiltration of Mononuclear Cells in Primary Sj\u00f6gren's Syndrome Through Interferon\u2010Induced Protein With Tetratricopeptide Repeats 1\u2013Mediated Up\u2010Regulation of\n CXCL<\/scp>\n 10"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-1538","authenticated-orcid":false,"given":"Qingqing","family":"Tian","sequence":"first","affiliation":[{"name":"Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University Wenzhou 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