{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:43:48Z","timestamp":1792802628285,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AR070892"],"award-info":[{"award-number":["K24 AR070892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR062506"],"award-info":[{"award-number":["R01 AR062506"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Pain sensitization contributes to the complex osteoarthritis (OA) pain experience. The relationship between imaging features of hand OA and clinically assessed pain sensitization is largely unexplored. This study was undertaken to examine the association of structural and inflammatory features of hand OA with local pressure pain thresholds (PPTs) in the Nor\u2010Hand study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cross\u2010sectional relationship of severity of structural radiographic features of hand OA (measured according to the Kellgren\/Lawrence scale [grade 0\u20134] and the absence or presence of erosive joint disease) as well as ultrasound\u2010detected hand joint inflammation (assessed by gray\u2010scale synovitis [grade 0\u20133] and the absence or presence of power Doppler activity) to the PPTs of 2 finger joints was examined by multilevel regression analyses adjusted for age, sex, and body mass index, using beta values with 95% confidence intervals (95% CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 570 joints in 285 participants included in the Nor\u2010Hand study were assessed. Greater structural and inflammatory severity was associated with lower PPTs, with adjusted beta values of \u22120.5 (95% CI \u22120.6, \u22120.4) per Kellgren\/Lawrence grade increase, \u22121.4 (95% CI \u22121.8, \u22120.9) for erosive versus non\u2010erosive joints, \u22120.7 (95% CI \u22120.9, \u22120.6) per gray\u2010scale synovitis grade increase, and \u22121.5 (95% CI \u22121.8, \u22121.1) for joints with power Doppler activity on ultrasound versus those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Greater severity of structural pathologic features and hand joint inflammation was associated with lower PPTs in the finger joints of patients with hand OA, indicating pain sensitization. Our results indicate that pain sensitization might be driven by structural and inflammatory pathology in hand OA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41199","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T05:50:37Z","timestamp":1578289837000},"page":"966-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Associations Between Radiographic and Ultrasound\u2010Detected Features in Hand Osteoarthritis and Local Pressure Pain Thresholds"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-4255","authenticated-orcid":false,"given":"Pernille","family":"Steen Pettersen","sequence":"first","affiliation":[{"name":"Diakonhjemmet Hospital and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-1711","authenticated-orcid":false,"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-5794","authenticated-orcid":false,"given":"Karin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital, Oslo, Norway, and Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-8991","authenticated-orcid":false,"given":"Hilde Berner","family":"Hammer","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-9552","authenticated-orcid":false,"given":"Till","family":"Uhlig","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-3093","authenticated-orcid":false,"given":"Tore K.","family":"Kvien","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-2216","authenticated-orcid":false,"given":"Ida K.","family":"Haugen","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex522"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150078"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.04.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206829"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.124875"},{"issue":"107","key":"e_1_2_7_7_1","first-page":"68","article-title":"Pain sensitisation in osteoarthritis","volume":"35","author":"Arendt\u2010Nielsen L","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40850"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex419"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.06.009"},{"issue":"107","key":"e_1_2_7_11_1","first-page":"75","article-title":"Structural correlates of pain in osteoarthritis","volume":"35","author":"Neogi T","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/703138"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016938"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390221"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0337"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.077081"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S147640"}],"container-title":["Arthritis &amp; 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