{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:10:43Z","timestamp":1792807843684,"version":"4.5.0"},"reference-count":118,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To provide guidance for the management of gout, including indications for and optimal use of urate\u2010lowering therapy (<jats:styled-content style=\"fixed-case\">ULT<\/jats:styled-content>), treatment of gout flares, and lifestyle and other medication recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010seven population, intervention, comparator, and outcomes questions were developed, followed by a systematic literature review, including network meta\u2010analyses with ratings of the available evidence according to the Grading of Recommendations Assessment, Development and Evaluation (<jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content>) methodology, and patient input. A group consensus process was used to compose the final recommendations and grade their strength as strong or conditional.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two recommendations (including 16 strong recommendations) were generated. Strong recommendations included initiation of <jats:styled-content style=\"fixed-case\">ULT<\/jats:styled-content> for all patients with tophaceous gout, radiographic damage due to gout, or frequent gout flares; allopurinol as the preferred first\u2010line <jats:styled-content style=\"fixed-case\">ULT<\/jats:styled-content>, including for those with moderate\u2010to\u2010severe chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>; stage <jats:styled-content>&gt;<\/jats:styled-content>3); using a low starting dose of allopurinol (\u2264100 mg\/day, and lower in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) or febuxostat (<jats:styled-content>&lt;<\/jats:styled-content>40 mg\/day); and a treat\u2010to\u2010target management strategy with <jats:styled-content style=\"fixed-case\">ULT<\/jats:styled-content> dose titration guided by serial serum urate (<jats:styled-content style=\"fixed-case\">SU<\/jats:styled-content>) measurements, with an <jats:styled-content style=\"fixed-case\">SU<\/jats:styled-content> target of &lt;6 mg\/dl. When initiating <jats:styled-content style=\"fixed-case\">ULT<\/jats:styled-content>, concomitant antiinflammatory prophylaxis therapy for a duration of at least 3\u20136 months was strongly recommended. For management of gout flares, colchicine, nonsteroidal antiinflammatory drugs, or glucocorticoids (oral, intraarticular, or intramuscular) were strongly recommended.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> methodology and informed by a consensus process based on evidence from the current literature and patient preferences, this guideline provides direction for clinicians and patients making decisions on the management of gout.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41247","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T01:01:15Z","timestamp":1589158875000},"page":"879-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":403,"title":["2020 American College of Rheumatology Guideline for the Management of Gout"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-7538","authenticated-orcid":false,"given":"John D.","family":"FitzGerald","sequence":"first","affiliation":[{"name":"University of California, Los Angeles and VA Greater Los Angeles Health Care System  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-2272","authenticated-orcid":false,"given":"Ted","family":"Mikuls","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and VA Nebraska\u2013Western Iowa Health Care System  Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Brignardello\u2010Petersen","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Guyatt","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2940-7114","authenticated-orcid":false,"given":"Aryeh M.","family":"Abeles","sequence":"additional","affiliation":[{"name":"New York University School of Medicine  New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-311X","authenticated-orcid":false,"given":"Allan C.","family":"Gelber","sequence":"additional","affiliation":[{"name":"Johns Hopkins University  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie R.","family":"Harrold","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School Worcester Massachusetts, and Corrona  Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-4453","authenticated-orcid":false,"given":"Dinesh","family":"Khanna","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"King","sequence":"additional","affiliation":[{"name":"North Mississippi Medical Center  Tupelo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Levy","sequence":"additional","affiliation":[{"name":"Kaiser Permanente  Downey California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn","family":"Libbey","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mount","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-1542","authenticated-orcid":false,"given":"Michael H.","family":"Pillinger","sequence":"additional","affiliation":[{"name":"New York University School of Medicine  New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin  Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-0006","authenticated-orcid":false,"given":"Jasvinder A.","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center  Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Edward","family":"Sims","sequence":"additional","affiliation":[{"name":"Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-0473","authenticated-orcid":false,"given":"Benjamin J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Florida State University College of Medicine School of Physician Assistant Practice  Tallahassee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil S.","family":"Wenger","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-7219","authenticated-orcid":false,"given":"Sangmee Sharon","family":"Bae","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Danve","sequence":"additional","affiliation":[{"name":"Yale University  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja P.","family":"Khanna","sequence":"additional","affiliation":[{"name":"University of Michigan VA Ann Arbor Healthcare System  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-3579","authenticated-orcid":false,"given":"Seoyoung C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Lenert","sequence":"additional","affiliation":[{"name":"University of Kentucky  Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Poon","sequence":"additional","affiliation":[{"name":"US Department of Veterans Affairs  Manchester New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anila","family":"Qasim","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv T.","family":"Sehra","sequence":"additional","affiliation":[{"name":"Mount Auburn Hospital  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun Sudhir Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Allegheny Health Network  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Toprover","sequence":"additional","affiliation":[{"name":"New York University School of Medicine  New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Turgunbaev","sequence":"additional","affiliation":[{"name":"American College of Rheumatology  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linan","family":"Zeng","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0087-1039","authenticated-orcid":false,"given":"Mary Ann","family":"Zhang","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Turner","sequence":"additional","affiliation":[{"name":"American College of Rheumatology  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-1711","authenticated-orcid":false,"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40807"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140588"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.7.925"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22767"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21773"},{"key":"e_1_2_8_8_1","first-page":"309","article-title":"Summary of the Dutch College of General Practitioners\u2019 \u201cGout\u201d Standard","volume":"146","author":"Romeijnders AC","year":"2002","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055269"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem056a"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209707"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204463"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.4.437"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.6680"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2426"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.05.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027445"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40674-015-0014-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21955"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.02.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4318"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111375"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1169"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex350"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40159"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20405"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40233"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131159"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131240"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-363"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0047-z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90441-4"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01760213"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611273152204"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.4310"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.06.028"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30649"},{"key":"e_1_2_8_39_1","volume-title":"Zyloprim (allopurinol) product information","year":"2018"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34488"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210872"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211574"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.9.545"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32158-5"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12799"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211873"},{"key":"e_1_2_8_47_1","first-page":"2429","article-title":"Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis","volume":"31","author":"Borstad GC","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket114"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170517"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39684"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144063"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21690"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131226"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207984"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2017.1318467"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050373"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24209"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000235"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.05.025"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.02.021"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/15-234"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.11.011"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-9-200111060-00012"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22741"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409500102"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328330a3b8"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1166"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.10.009"},{"key":"e_1_2_8_69_1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1136\/annrheumdis-2017-212905","article-title":"Racial\/ethnic variation and risk factors for allopurinol\u2010associated severe cutaneous adverse reactions: a cohort study","volume":"77","author":"Keller SF","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<231::AID-ANR30>3.0.CO;2-7"},{"key":"e_1_2_8_71_1","first-page":"295","article-title":"Allopurinol desensitization: a fast or slow protocol?","volume":"25","author":"Soares J","year":"2015","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_8_72_1","unstructured":"US Food and Drug Administration.FDA adds boxed warning for increased risk of death with gout medicine Uloric (febuxostat). URL:https:\/\/www.fda.gov\/drugs\/\u200bdrug-safety-and-avail\u200babili\u200bty\/fda-adds-boxed-warni\u200bng-incre\u200based-risk-death-gout-medic\u200bine-uloric-febux\u200bostat."},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710895"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033992"},{"key":"e_1_2_8_75_1","first-page":"393","article-title":"Major cardiovascular events in patients with gout and associated cardiovascular disease or heart failure and chronic kidney disease initiating a xanthine oxidase inhibitor","volume":"10","author":"Foody J","year":"2017","journal-title":"Am Health Drug Benefits"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20221"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39840"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201795"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38323"},{"key":"e_1_2_8_80_1","first-page":"111","article-title":"Comparison of triamcinolone acetonide with indomethacin in the treatment of acute gouty arthritis","volume":"20","author":"Alloway JA","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_8_81_1","first-page":"1325","article-title":"Comparison of adrenocorticotropic hormone and triamcinolone acetonide in the treatment of acute gouty arthritis","volume":"21","author":"Siegel LB","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310618"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2006.11.014"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60799-0"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27600"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110916"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4159"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12359"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12521"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200908"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3297"},{"key":"e_1_2_8_92_1","first-page":"331","article-title":"Local ice therapy during bouts of acute gouty arthritis","volume":"29","author":"Schlesinger N","year":"2002","journal-title":"J\u00a0Rheumatol"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3951"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2500"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200801"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6637.1641-a"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.1.31"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.12.019"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201215"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12661"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92269-5"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23245"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1638"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440101"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211472"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22954"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203970"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2014.02.025"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.7.539"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37925"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161205774913309"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.171488"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30029-9"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23500"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10511"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-016-9871-8"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/17-142"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000585"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201687"}],"updated-by":[{"DOI":"10.1002\/art.41688","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000}}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.41247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.41247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.41247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.41247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:40:52Z","timestamp":1759941652000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.41247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":118,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/art.41247"],"URL":"https:\/\/doi.org\/10.1002\/art.41247","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1002\/art.41688","asserted-by":"object"}]},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,11]]},"assertion":[{"value":"2019-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}