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The OA<\/jats:styled-content> phenotype that resulted was evaluated by assessing joint morphology and sulfated glycosaminoglycan (sGAG<\/jats:styled-content>) staining via histological analysis (n = 6 mice per group), surface collagen fibril nanostructure via scanning electron microscopy (n = 4 mice per group), tissue modulus via atomic force microscopy\u2013nanoindentation (n = 5 or more mice per group) and subchondral bone structure via micro\u2013computed tomography (n = 5 mice per group). Femoral head cartilage explants from wild\u2010type and Dcn\u2212\/\u2212<\/jats:sup> mice were stimulated with the inflammatory cytokine interleukin\u20101\u03b2 (IL<\/jats:styled-content>\u20101\u03b2) in vitro (n = 6 mice per group). The resulting chondrocyte response to IL<\/jats:styled-content>\u20101\u03b2 and release of sGAG<\/jats:styled-content>s were quantified.<\/jats:p><\/jats:sec>Results<\/jats:title>In both Dcn\u2212\/\u2212<\/jats:sup> and Dcni<\/jats:sup>KO<\/jats:sup><\/jats:styled-content> mice, the absence of decorin resulted in accelerated sGAG<\/jats:styled-content> loss and formation of highly aligned collagen fibrils on the cartilage surface relative to the control (P<\/jats:italic> < 0.05). Also, Dcn\u2212\/\u2212<\/jats:sup> mice developed more salient osteophytes, illustrating more severe OA<\/jats:styled-content>. In cartilage explants treated with IL<\/jats:styled-content>\u20101\u03b2, loss of decorin did not alter the expression of either anabolic or catabolic genes. However, a greater proportion of sGAG<\/jats:styled-content>s was released to the media from Dcn\u2212\/\u2212<\/jats:sup> mouse explants, in both live and devitalized conditions (P<\/jats:italic> < 0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In post\u2010traumatic OA<\/jats:styled-content>, decorin delays the loss of fragmented aggrecan and fibrillation of cartilage surface, and thus, plays a protective role in ameliorating cartilage degeneration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41254","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T05:57:25Z","timestamp":1583992645000},"page":"1266-1277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Mediation of Cartilage Matrix Degeneration and Fibrillation by Decorin in Post\u2010traumatic Osteoarthritis"],"prefix":"10.1002","volume":"72","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[{"name":"Drexel University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Han","sequence":"additional","affiliation":[{"name":"Drexel University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Drexel University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tong","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Wei","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ju","family":"Tseng","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hsin","family":"Han","sequence":"additional","affiliation":[{"name":"Drexel University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. 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