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The present study was undertaken to explore the potential beneficial effects of this strategy of pharmacologic inhibition using novel anti\u2010BAMBI monoclonal antibodies (mAb) in different experimental murine models of chronic skin and joint inflammatory\/autoimmune disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Development of <jats:italic>Saccharomyces cerevisiae<\/jats:italic> mannan\u2013induced psoriatic arthritis (MIP) (n = 18\u201330 mice per group), imiquimod\u2010induced skin psoriasis (n = 20\u201330 mice per group), or type II collagen\u2013induced arthritis (CIA) (n = 13\u201316 mice per group) was analyzed in a total of 2\u20135 different experiments with either wild\u2010type (WT) or BAMBI\u2010deficient B10.RIII mice that were left untreated or treated with mAb B101.37 (mouse IgG1 anti\u2010BAMBI), a mouse IgG1 anti\u2010TNP isotype control, anti\u2010CD25, or anti\u2010TGF\u03b2 mAb.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment of normal mice with IgG1 anti\u2010BAMBI mAb clone B101.37 led to expansion of Treg cells in vivo, and had both preventive and therapeutic effects in mice with MIP (each <jats:italic>P<\/jats:italic> &lt; 0.05 versus controls). The conferred protection against disease progression was found to be mediated by Treg cells, which controlled the activation and expansion of pathogenic IL\u201017\u2013producing cells, and was dependent on the level of TGF\u03b2 activity. Furthermore, treatment with B101.37 mAb blocked both the development of skin psoriasis induced by imiquimod and the development of CIA in mice (each <jats:italic>P<\/jats:italic> &lt; 0.05 versus controls). Finally, pharmacologic inhibition of BAMBI with the IgM anti\u2010BAMBI mAb B143.14 also potentiated the suppressive activity of Treg cells in vitro (<jats:italic>P<\/jats:italic> &lt; 0.001 versus controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results in murine models identify BAMBI as a promising new therapeutic target for chronic inflammatory diseases and other pathologic conditions modulated by Treg cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41272","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T04:09:42Z","timestamp":1586146182000},"page":"1547-1558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic Effects of Anti\u2013Bone Morphogenetic Protein and Activin Membrane\u2010Bound Inhibitor Treatment in Psoriasis and 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