{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:17:04Z","timestamp":1787156224117,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"am","delay-in-days":249,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY\u2010025373"],"award-info":[{"award-number":["EY\u2010025373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR\u2010120641"],"award-info":[{"award-number":["PR\u2010120641"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"\n Objective<\/jats:title>\n \n CD<\/jats:styled-content>\n 6 is an important regulator of T cell function that interacts with the ligands\n CD<\/jats:styled-content>\n 166 and\n CD<\/jats:styled-content>\n 318. To further clarify the significance of\n CD<\/jats:styled-content>\n 6 in rheumatoid arthritis (\n RA<\/jats:styled-content>\n ), we examined the effects of targeting\n CD<\/jats:styled-content>\n 6 in the mouse model of collagen\u2010induced arthritis (\n CIA<\/jats:styled-content>\n ), using\n CD<\/jats:styled-content>\n 6\u2010knockout (\n CD<\/jats:styled-content>\n 6\u2010\n KO<\/jats:styled-content>\n ) mice and\n CD<\/jats:styled-content>\n 6\u2010humanized mice that express human\n CD<\/jats:styled-content>\n 6 in lieu of mouse\n CD<\/jats:styled-content>\n 6 on their T cells.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We immunized wild\u2010type (\n WT<\/jats:styled-content>\n ) and\n CD<\/jats:styled-content>\n 6 gene\u2013\n KO<\/jats:styled-content>\n mice with a collagen emulsion to induce\n CIA<\/jats:styled-content>\n . For treatment studies using\n CD<\/jats:styled-content>\n 6\u2010humanized mice, mice were immunized similarly and a mouse anti\u2010human\n CD<\/jats:styled-content>\n 6 IgG (\n UMCD<\/jats:styled-content>\n 6) or control IgG was injected on days 7, 14, and 21. Joint tissues were evaluated for tissue damage, leukocyte infiltration, and local inflammatory cytokine production. Collagen\u2010specific Th1, Th9, and Th17 responses and serum levels of collagen\u2010specific IgG subclasses were also evaluated in\n WT<\/jats:styled-content>\n and\n CD<\/jats:styled-content>\n 6\u2010\n KO<\/jats:styled-content>\n mice with\n CIA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The absence of\n CD<\/jats:styled-content>\n 6 reduced 1) collagen\u2010specific Th9 and Th17, but not Th1 responses, 2) the levels of many proinflammatory joint cytokines, and 3) serum levels of collagen\u2010reactive total IgG and IgG1, but not IgG2a and IgG3. Joint homogenate hemoglobin content was significantly reduced in\n CD<\/jats:styled-content>\n 6\u2010\n KO<\/jats:styled-content>\n mice with\n CIA<\/jats:styled-content>\n compared to\n WT<\/jats:styled-content>\n mice with\n CIA<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.05) (reduced angiogenesis). Moreover, treating\n CD<\/jats:styled-content>\n 6\u2010humanized mice with mouse anti\u2010human\n CD<\/jats:styled-content>\n 6 monoclonal antibody was similarly effective in reducing joint inflammation in\n CIA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Taken together, these data suggest that interaction of\n CD<\/jats:styled-content>\n 6 with its ligands is important for the perpetuation of\n CIA<\/jats:styled-content>\n and other inflammatory arthritides that are T cell driven.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.41288","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T03:25:56Z","timestamp":1587353156000},"page":"1505-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Attenuation of Murine Collagen\u2010Induced Arthritis by Targeting\n CD<\/scp>\n 6"],"prefix":"10.1002","volume":"72","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-0321","authenticated-orcid":false,"given":"Jeffrey H.","family":"Ruth","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalana S.","family":"Athukorala","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Weber","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Asif","family":"Amin","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip L.","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora G.","family":"Singer","sequence":"additional","affiliation":[{"name":"MetroHealth Medical Center Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fox","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland 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