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We conducted a systematic review and meta\u2010analysis to describe the current evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search of published and preprint databases in all languages was performed. Included studies described \u22651 relevant clinical outcome for \u22655 patients who were infected with severe acute respiratory syndrome coronavirus 2 and were treated with antirheumatic disease therapy between January 1, 2019 and May 29, 2020. Pairs of reviewers screened articles, extracted data, and assessed risk of bias. A meta\u2010analysis of effect sizes using random\u2010effects models was performed when possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search identified 3,935 articles, of which 45 were included (4 randomized controlled trials, 29 cohort studies, and 12 case series). All studies evaluated hospitalized patients, and 29 of the 45 studies had been published in a peer\u2010reviewed journal. In a meta\u2010analysis of 3 cohort studies with a low risk of bias, hydroxychloroquine use was not significantly associated with mortality (pooled hazard ratio [HR] 1.41 [95% confidence interval (95% CI) 0.83, 2.42]). In a meta\u2010analysis of 2 cohort studies with some concerns\/higher risk of bias, anakinra use was associated with lower mortality (pooled HR 0.25 [95% CI 0.12, 0.52]). Evidence was inconclusive with regard to other antirheumatic disease therapies, and the majority of other studies had a high risk of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this systematic review and meta\u2010analysis, hydroxychloroquine use was not associated with benefit or harm regarding COVID\u201019 mortality. The evidence supporting the effect of other antirheumatic disease therapies in COVID\u201019 is currently inconclusive.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41469","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T07:45:03Z","timestamp":1596354303000},"page":"36-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Antirheumatic Disease Therapies for the Treatment of COVID\u201019: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-4000","authenticated-orcid":false,"given":"Michael","family":"Putman","sequence":"first","affiliation":[{"name":"Northwestern Medicine  Chicago Illinois United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Pei Eugenia","family":"Chock","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-0639","authenticated-orcid":false,"given":"Herman","family":"Tam","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-0516","authenticated-orcid":false,"given":"Alfred H. 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