{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:40:43Z","timestamp":1793382043578,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Temporal arteritis (TA) is a typical manifestation of giant cell arteritis (GCA). Antineutrophil cytoplasmic antibody (ANCA)\u2013associated vasculitides (AAVs) are rarely revealed by TA manifestations, leading to a risk of misdiagnosis of GCA and inappropriate treatments. This study was undertaken to describe the clinical, biologic, and histologic presentations and outcomes in cases of TA revealing AAV (TA\u2010AAV) compared to controls with classic GCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective case\u2013control study, the characteristics of patients with TA\u2010AAV were compared to those of control subjects with classic GCA. Log\u2010rank test, with hazard ratios (HRs) and 95% confidence intervals (95% CIs), was used to assess the risk of treatment failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty patients with TA\u2010AAV (median age 70 years) were included. Thirty\u2010three patients (66%) presented with atypical symptoms of GCA (ear, nose, and throat involvement in 32% of patients, and renal, pulmonary, and neurologic involvement in 26%, 20%, and 16% of patients, respectively). Blood samples were screened for ANCAs at the time of disease onset in 33 patients, and results were positive in 88%, leading to a diagnosis of early TA\u2010AAV in 20 patients. The diagnosis of AAV was delayed a median interval of 15 months in 30 patients. Compared to controls with GCA, patients with TA\u2010AAV were younger (median age 70 years versus 74 years), were more frequently men (48% versus 30%), and had high frequencies of atypical manifestations and higher C\u2010reactive protein levels (median 10.8 mg\/dl versus 7.0 mg\/dl). In patients with TA\u2010AAV, temporal artery biopsy (TAB) showed fibrinoid necrosis and small branch vasculitis in 23% of patients each, whereas neither of these characteristics was evident in controls with GCA. Treatment failure\u2013free survival was comparable between early TA\u2010AAV cases and GCA controls, whereas those with delayed TA\u2010AAV had a significantly higher risk of treatment failure compared to controls (HR 3.85, 95% CI 1.97\u20137.51;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TA\u2010AAV should be considered diagnostically in cases of atypical manifestations of GCA, refractoriness to glucocorticoid treatment, or early relapse. Analysis of TAB specimens for the detection of small branch vasculitis and\/or fibrinoid necrosis could be useful. Detection of ANCAs should be performed in cases of suspected GCA with atypical clinical features and\/or evidence of temporal artery abnormalities on TAB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.41527","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T04:29:35Z","timestamp":1600576175000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Temporal Arteritis Revealing Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitides: A Case\u2013Control Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-7193","authenticated-orcid":false,"given":"Laure","family":"Delaval","sequence":"first","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Syst\u00e9miques Rares d\u2019Ile\u2010de\u2010France H\u00f4pital Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Samson","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) de Dijon Bourgogne  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Schein","sequence":"additional","affiliation":[{"name":"H\u00f4pital Nord  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Agard","sequence":"additional","affiliation":[{"name":"CHU de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Tr\u00e9fond","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Deroux","sequence":"additional","affiliation":[{"name":"CHU de Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Dupuy","sequence":"additional","affiliation":[{"name":"H\u00f4pital Haut\u2010L\u00e9v\u00eaque  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Garrouste","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Godmer","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Bretagne Atlantique  Vannes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Landron","sequence":"additional","affiliation":[{"name":"CHU de Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Maurier","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Priv\u00e9s de Metz  Metz France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"le Guenno","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Rieu","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Desblache","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Pau  Pau France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-5017","authenticated-orcid":false,"given":"C\u00e9cile\u2010Audrey","family":"Durel","sequence":"additional","affiliation":[{"name":"H\u00f4pital Edouard Herriot and Hospices Civiles de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Jousselin\u2010Mahr","sequence":"additional","affiliation":[{"name":"H\u00f4pital St. Antoine AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Kassem","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Sud Essonne Dourdan\u2010Etampes  Dourdan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Pugnet","sequence":"additional","affiliation":[{"name":"CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivane","family":"Queyrel","sequence":"additional","affiliation":[{"name":"H\u00f4pital Pasteur 2  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Swiader","sequence":"additional","affiliation":[{"name":"CHU de Marseille H\u00f4pital de la Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-1780","authenticated-orcid":false,"given":"Daniel","family":"Blockmans","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-234X","authenticated-orcid":false,"given":"Karim","family":"Sacr\u00e9","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bichat\u2010Claude Bernard AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estibaliz","family":"Lazaro","sequence":"additional","affiliation":[{"name":"H\u00f4pital Haut\u2010L\u00e9v\u00eaque  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Syst\u00e9miques Rares d\u2019Ile\u2010de\u2010France H\u00f4pital Cochin, and Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Auma\u00eetre","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Cath\u00e9bras","sequence":"additional","affiliation":[{"name":"H\u00f4pital Nord  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Guillevin","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Syst\u00e9miques Rares d\u2019Ile\u2010de\u2010France H\u00f4pital Cochin, and Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-7336","authenticated-orcid":false,"given":"Benjamin","family":"Terrier","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Syst\u00e9miques Rares d\u2019Ile\u2010de\u2010France H\u00f4pital Cochin, and Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the French Vasculitis Study Group and French Study Group for Giant Cell Arteritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330810"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330803"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2001.16650"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61077-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000244"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199912)42:12<2674::AID-ANR25>3.0.CO;2-A"},{"key":"e_1_2_7_9_1","first-page":"707","article-title":"A case of Wegener\u2019s granulomatosis presenting with jaw claudication","volume":"11","author":"Vermeulen JP","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2007.08.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6913-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-012-0610-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-003-0816-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.17992"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.6.1539"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-1052-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.054593"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.017"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209507"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.140"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330804"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206404"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613849"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00560-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10262"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2008.01.011"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.41527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.41527","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.41527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:50:20Z","timestamp":1759953020000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.41527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,21]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/art.41527"],"URL":"https:\/\/doi.org\/10.1002\/art.41527","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,21]]},"assertion":[{"value":"2019-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}