{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:11:46Z","timestamp":1794258706212,"version":"4.9.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014338","name":"National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care Yorkshire and Humber","doi-asserted-by":"publisher","award":["CS\u20102018\u201018\u2010ST2\u2010005"],"award-info":[{"award-number":["CS\u20102018\u201018\u2010ST2\u2010005"]}],"id":[{"id":"10.13039\/501100014338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","award":["V0419"],"award-info":[{"award-number":["V0419"]}],"id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Children with juvenile idiopathic arthritis (JIA) need regular examinations for uveitis to avoid visual morbidity from the most common extraarticular manifestation of disease. This study was undertaken to investigate the feasibility, acceptability, and performance of optical coherence tomography (OCT) imaging\u2010based diagnosis of uveitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational cross\u2010sectional study included children with and those without uveitis. The children underwent routine clinical examinations and anterior segment OCT scanning of intraocular inflammatory cells. Acceptability of image acquisition was assessed using a visual analog scale and length of time needed to acquire images. Interobserver and intraobserver variability of manual counting of acquired images (Bland\u2010Altman limits of agreement), correlation between imaging and routine assessment, and sensitivity and specificity of anterior segment OCT detection of active inflammation were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 26 children ages 3\u201315 years (median age 8 years) who underwent imaging, 12 had active inflammation. All patients rated the acceptability of image acquisition as at least 8.5 on a scale of 0\u201310. Time taken to acquire images ranged from 1.5 minutes to 22 minutes (median time 8 minutes). There was good positive correlation between clinical assessment and image\u2010based cell quantification (R<jats:sup>2<\/jats:sup> = 0.63, <jats:italic>P<\/jats:italic> = 0.002). Sensitivity of anterior segment OCT manual image cell count for diagnosis of active inflammation was 92% (95% confidence interval [95% CI] 62\u201399%), specificity was 86% (95% CI 58\u201398%), and negative predictive value (ruling out uveitis) was 92% (95% CI 65\u201399%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010contact, high\u2010resolution imaging for JIA uveitis surveillance is feasible, acceptable to patients, and holds the promise of transforming pediatric practice. Further work is needed to determine the analytic and clinical validity of anterior segment OCT quantification of active inflammation, and the clinical utility and cost\u2010effectiveness of imaging\u2010based disease monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41530","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T14:56:51Z","timestamp":1601045811000},"page":"330-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Imaging\u2010Based Uveitis Surveillance in Juvenile Idiopathic Arthritis: Feasibility, Acceptability, and Diagnostic Performance"],"prefix":"10.1002","volume":"73","author":[{"given":"Saira","family":"Akbarali","sequence":"first","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jugnoo S.","family":"Rahi","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust University College London Great Ormond Street Institute of Child Health NIHR Great Ormond Street Hospital Biomedical Research Centre NIHR Moorfields Biomedical Research Centre Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Dick","sequence":"additional","affiliation":[{"name":"NIHR Moorfields Biomedical Research Centre Moorfields Eye Hospital NHS Foundation Trust University College London Institute of Ophthalmology, London, UK, and Bristol Eye Hospital University Hospitals Bristol NHS Foundation Trust University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiren","family":"Parkash","sequence":"additional","affiliation":[{"name":"University of Birmingham Medical School  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Etherton","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Edelsten","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust, London UK, and Ipswich Hospital NHS Foundation Trust  Ipswich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Birmingham College of Medical and Dental Sciences, and University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-5864","authenticated-orcid":false,"given":"Ameenat L.","family":"Solebo","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust University College London Great Ormond Street Institute of Child Health NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.09.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0018-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23871"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38304"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20269"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2019.1640883"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2016.10.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2031-8"},{"key":"e_1_2_7_11_1","first-page":"959","article-title":"Visual function, social position, and health and life chances: the UK Biobank Study","volume":"134","author":"Cumberland PM","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17469899.2020.1739521"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.06.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12150"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0518-8"},{"key":"e_1_2_7_16_1","unstructured":"Royal College of Ophthalmologists.Workforce census 2018. 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