{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:32:28Z","timestamp":1790677948059,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ20150934719"],"award-info":[{"award-number":["DEQ20150934719"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Primary Sj\u00f6gren\u2019s syndrome (SS) is characterized by a lymphocytic infiltration of salivary glands (SGs) and the presence of an interferon (IFN) signature. SG epithelial cells (SGECs) play an active role in primary SS pathophysiology. We undertook this study to examine the interactions between SGECs and T cells in primary SS and the role of the interleukin\u20107 (IL\u20107)\/IFN axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary cultured SGECs from control subjects and patients with primary SS were stimulated with poly(I\u2010C), IFN\u03b1, or IFN\u03b3. T cells were sorted from blood and stimulated with IL\u20107. CD25 expression was assessed by flow cytometry. SG explants were cultured for 4 days with anti\u2013IL\u20107 receptor (IL\u20107R) antagonist antibody (OSE\u2010127), and transcriptomic analysis was performed using the NanoString platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum IL\u20107 level was increased in patients with primary SS compared to controls and was associated with B cell biomarkers.\n                      <jats:italic>IL7R<\/jats:italic>\n                      expression was decreased in T cells from patients with primary SS compared to controls. SGECs stimulated with poly(I\u2010C), IFN\u03b1, or IFN\u03b3 secreted IL\u20107. IL\u20107 stimulation increased the activation of T cells, as well as IFN\u03b3 secretion. Transcriptomic analysis of SG explants showed a correlation between\n                      <jats:italic>IL7<\/jats:italic>\n                      and\n                      <jats:italic>IFN<\/jats:italic>\n                      expression. Finally, explants cultured with anti\u2013IL\u20107R antibody showed decreased IFN\u2010stimulated gene expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest the presence of an IL\u20107\/IFN\u03b3 amplification loop involving SGECs and T cells in primary SS. IL\u20107 was secreted by SGECs stimulated with type I or type II IFN and, in turn, activated T cells that secrete type II IFN. An anti\u2013IL\u20107R antibody decreased the IFN signature in T cells in primary SS and could be of therapeutic interest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.41558","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T11:24:42Z","timestamp":1602761082000},"page":"631-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Interleukin\u20107\/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-3081","authenticated-orcid":false,"given":"Elodie","family":"Rivi\u00e8re","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay INSERM CEA Centre de Recherche en Immunologie des Infections Virales et des Maladies Auto\u2010Immunes H\u00f4pital Bic\u00eatre AP\u2010HP Recherche et D\u00e9veloppement Arthritis Fondation Courtin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Pascaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay INSERM CEA Centre de Recherche en Immunologie des Infections Virales et des Maladies Auto\u2010Immunes H\u00f4pital Bic\u00eatre AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Virone","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay INSERM CEA Centre de Recherche en Immunologie des Infections Virales et des Maladies Auto\u2010Immunes H\u00f4pital Bic\u00eatre AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Dupr\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay INSERM CEA Centre de Recherche en Immunologie des Infections Virales et des Maladies 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